Dyspnea Clinical Trial - The Safety & Efficacy of FFR Protocol in NTUH

Status Recruiting

Clinical Trial Summary

FFR-guided PCI has been performed in National Taiwan University Hospital(NTUH) for many years. Nevertheless, the method of FFR measurement in NTUH is different from that in literature. In this study, the investigator would like to evaluate the effectiveness and safety of NTUH experience in FFR prospectively. First, the investigator will record any intracoronary (IC) injected adenosine-related complications, such as bradyarrhythmia or chest discomfort. Second, the investigator will follow up on the clinical outcome of the participants for 2 years, record if any target lesion failure, target vessel failure, target vessel-related myocardial infarction, and cardiac death. Finally, left ventricular diastolic pressure, serum pro-brain natriuretic peptide (pro-BNP), and high sensitivity C- reactive protein (hsCRP) will be checked and determined their relationships with the maximum dosage of IC adenosine.

Clinical Trial Description

FFR has been introduced for the determination of physiological ischemia in the myocardium for many years. Nowadays, FFR-guided PCI is highly recommended for the assessment of physiologic ischemia in intermediate coronary lesions. FFR-guided PCI has been performed in National Taiwan University Hospital(NTUH) for many years. Nevertheless, the method of FFR measurement in NTUH is different from that in literature. In this study, the investigator would like to evaluate the effectiveness and safety of NTUH experience in FFR prospectively. First, the investigator will record any intracoronary (IC) injected adenosine-related complications, such as bradyarrhythmia or chest discomfort. Second, the investigator will follow up on the clinical outcome of the participants for 2 years, record if any target lesion failure, target vessel failure, target vessel-related myocardial infarction, and cardiac death. Finally, left ventricular diastolic pressure, serum pro-brain natriuretic peptide (pro-BNP), and high sensitivity C- reactive protein (hsCRP) will be checked and determined their relationships with the maximum dosage of IC adenosine. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03693157
Study type	Observational [Patient Registry]
Source	National Taiwan University Hospital Hsin-Chu Branch
Contact	Chien-Boon Jong, MD
Phone	+88635322140
Email	jgboon0407@gmail.com
Status	Recruiting
Phase
Start date	November 7, 2018
Completion date	December 31, 2022

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT04688905` - Diagnosing Heart Failure With Preserved Ejection Fraction in Patients With Unexplained Dyspnea (Diagnose-HFpEF)
Completed	`NCT03679312` - The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD	Phase 1/Phase 2
Recruiting	`NCT04868357` - Hypnosis for the Management of Anxiety and Breathlessness During a Pulmonary Rehabilitation Program	N/A
Active, not recruiting	`NCT03604822` - Music Therapy Protocol to Support Bulbar and Respiratory Functions in ALS	N/A
Completed	`NCT03626519` - Effects of Menthol on Dyspnoea in COPD Patients	N/A
Completed	`NCT02638649` - Prehospital Use of Ultrasound in Undifferentiated Shortness of Breath
Completed	`NCT02248831` - Evaluation of Cardiopulmonary Diseases by Ultrasound	N/A
Completed	`NCT02538770` - Rapid Viral Diagnostics in Adults to Reduce Antimicrobial Consumption and Duration of Hospitalization	N/A
Terminated	`NCT02269761` - Chest Ultrasound of ER Patients With Cough or SOB
Recruiting	`NCT01655199` - Sensitivity of the Step Test to Detect Improvement in Dyspnea Following Bronchodilation in Patients With Chronic Obstructive Pulmonary Disease	N/A
Active, not recruiting	`NCT01440764` - Aerosol Inhalation Treatment for Dyspnea	Phase 1/Phase 2
Completed	`NCT01577407` - Non Opioid Treatment for Experimental Dyspnea	Phase 3
Completed	`NCT01193998` - Impact of Validated Diagnostic Prediction Model of Acute Heart Failure in the Emergency Department	N/A
Recruiting	`NCT04327882` - Point-of-care Ultrasound Interest in Dyspneic Emergency Department Patients: an Observational Bicentric Study
Completed	`NCT05029986` - Preventing Dyspnea During Speech in Older Speakers	N/A
Not yet recruiting	`NCT04181359` - The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in Interstitial Lung Disease.	Phase 1/Phase 2
Recruiting	`NCT04615065` - Acutelines: a Large Data-/Biobank of Acute and Emergency Medicine
Completed	`NCT04305639` - The Reliability and Validity of Turkish Version of ''The Dyspnea-ALS-Scale (DALS-15)"
Completed	`NCT04375917` - Is Reduced Hypoxia Through a Robot Intervention, Associated With Sensory and Emotional Descriptions of Dyspnea, Anxiety, Depression, Symptom Burden and Anxiolytics	N/A
Completed	`NCT04370990` - Automated Oxygen Administration -Rethinking Interventions Alleviating Dyspnea in Patients With COPD	N/A

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.

The Safety and Efficacy of FFR Protocol in NTUH System

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms