Clinical Trials Logo
  1. Home
  2. Dysphonia
  3. NCT05110417

Reversal of Botulinum Neurotoxin Injection Related Dysphonia With Pyridostigmine

Dysphonia Clinical Trial

Official title:
Pilot Study of the Efficacy of Pyridostigmine for Reversal of Post Injection Dysphonia Following Botulinum Neurotoxin Laryngeal Chemo-Denervation in Spasmodic Dysphonia

Clinical Trial Summary

The purpose of this study is to evaluate the effects of pyridostigmine (Mestinon) on patient vocal outcomes after undergoing laryngeal botulinum neurotoxin (BoNT) injections, which is a standard treatment for spasmodic dysphonia. Pyridostigmine (Mestinon) has been used for treatment of BoNT overdose, and it is our hope that it will be beneficial in the management of post BoNT breathy phase.

Clinical Trial Description

The study will enroll 10 subjects and will involve 1 clinic visit with two sessions over 2 hours. Participants' voices will then be analyzed via sentence/passage reading, sustained vowel holding, maximum phonation time, as well as subjective ratings of effort. During the second clinic visit, participants will then be administered one 60mg tablet of pyridostigmine (Mestinon) orally, and asked to return to the clinic in 2 hours, when Mestinon has reached peak plasma concentration. Upon returning, participants will repeat the vocal analysis and results will be evaluated for any change in outcome. Patients who are pregnant, lactating, or have kidney or heart disease should not participate. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05110417
Study type Interventional
Source Eastern Virginia Medical School
Contact Addy Tham, MS
Phone 757.388.6264
Email thama@evms.edu
Status Recruiting
Phase Phase 4
Start date May 20, 2021
Completion date June 1, 2023
View Details
See also
  Status Clinical Trial Phase
Enrolling by invitation NCT04713033 - Computational Cranial and Cervical Muscle Network in Normal and Disordered Voice N/A
Not yet recruiting NCT02724761 - Prophylactic Racemic Epinephrine in Anterior Cervical Discectomy and Fusion N/A
Recruiting NCT04584658 - Dysphagia and Dysphonia Outcomes in SARS CoV-2 (COVID-19) Infection (DYADS Study)
Not yet recruiting NCT03692494 - The Effects of Adding Expiratory Muscle Strength Training in Voice Therapy N/A
Recruiting NCT01017055 - Voice and Swallowing Outcomes Following Revision Anterior Cervical Spine Surgery
Recruiting NCT03720301 - The Use of Osteopathic Medical Manipulation to Decrease the Incidence and Severity of Post-Operative Sore Throat N/A
Completed NCT03240042 - Initial Increase in Cuff Pressure in Anterior Cervical Spinal Surgery N/A
Completed NCT02922309 - Comparing Telepractice and Conventional Face-to-face Voice Therapy N/A
Not yet recruiting NCT05479643 - A Personalized Voice Restoration Device for Patients With Laryngectomy N/A
Completed NCT05383417 - No Post Intubation Laryngeal Symptoms N/A
Completed NCT04591769 - Tracheal Tube Cuff Shape and Pressure N/A
Recruiting NCT06124053 - Investigation of the Effectiveness of Group Voice Therapy in Children N/A
Recruiting NCT05237648 - Assessing the Effects of Patient Self-Rating of Voice Quality on Voice Therapy Attendance and Outcomes N/A
Recruiting NCT05754606 - Artificial Intelligence and Benign Lesions of Vocal Folds Recognition
Not yet recruiting NCT03261141 - Correlation Between (PV-RQOL), The Auditory Perceptual Assessment and Acoustic Analysis of Voice in Dysphonic Children N/A
Recruiting NCT04290182 - A Study of Local Administration of Autologous Mesenchymal Stromal Cells in Dysphonic Patients With Vocal Fold Scarring Phase 1/Phase 2
Completed NCT03129880 - Intensive Versus Traditional Voice Therapy N/A
Active, not recruiting NCT05264961 - Behavioral Abnormalities in Dysphonic Children N/A
Completed NCT05410756 - Relationship Between Dysphonia And Anxiety In Fibromyalgia
Not yet recruiting NCT06328374 - Voice and Swallowing Disorders in Adults With and Without Alzheimer's Disease