Dyspepsia Clinical Trial
Official title:
A Two Week Nitazoxanidebased Quadruple Regimen for Helicobacter Pylori Therapy After Failure of Standard Triple Therapy: A Single Center Experience
Helicobacter pylori (H. pylori) infection is a global health problem as it is associated with
peptic ulcers, chronic gastritis, duodenitis, and stomach cancer.
Therefore, the eradication of the pathogen is of critical importance to reduce H.
pylori-related complications .
However, due to increasing antibiotic resistance, eradication of Helicobacter pylori has
become more challenging. With a great decline in the eradication rate of standard triple
therapy for Helicobacter pylori to below 70% in many countries.
Treatment with triple therapy, which is the most frequently recommended, fails to eradicate
H. pylori in approximately 20% of cases .
Designing a new rescue regimen that achieves greater than 85% eradication rate is an
important target of current research.
Unfortunately, the most frequently used "rescue" or "salvage" therapy is bismuth quadruple
therapy consisting of a proton pump inhibitor (PPI), tetracycline, metronidazole, and bismuth
[11]. This rescue therapy is inexpensive, and relatively effective with average eradication
rate of 70% when used as second-line therapy. However, disadvantages of bismuth based
quadruple therapy include the large daily number of pills (sometimes exceeding 18 pills),
increased dosing frequency (four times daily), and frequent side effects.
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