The Effect of Oxytocin on Gastric Emptying

Dyspepsia Clinical Trial

Official title:

The Effect of Oxytocin on Satiety in Patients With Dyspepsia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01152047
• Other study ID #: 2009/502
• Secondary ID: 2009/502
• Status: Completed
• Phase: N/A
• First received: June 23, 2010
• Last updated: April 6, 2015
• Start date: May 2010
• Est. completion date: April 2015

Study information

• Verified date: April 2015
• Source: Skane University Hospital
• Contact: n/a
• Is FDA regulated: No
• Health authority: Sweden: Regional Ethical Review Board
• Study type: Interventional

Clinical Trial Summary

The investigators have seen that oxytocin lowers satiety in healthy subjects. Patients with dyspepsia suffers from decreased accommodation and increased satiety postprandially. The investigators now want to examine whether oxytocin may diminish symptoms in these patients.

Description:

Patients will come twice for a slow satiety drinking test. Once they will get saline infusion and once oxytocin 40 mU/min. At the same time they register satiety on a VAS scale.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 14
• Est. completion date: April 2015
• Est. primary completion date: April 2015
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• Dyspepsia

Exclusion Criteria:

• Age > 65 years

• Cardiac disease

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Related Conditions & MeSH terms

• Dyspepsia
• Lack of Satiety

Intervention

Drug:
• oxytocin
40mU/min as infusion of oxytocin

Locations

Country	Name	City	State
Sweden	Skåne University Hospital	Malmö

Sponsors (1)

Lead Sponsor	Collaborator
Skane University Hospital

Country where clinical trial is conducted

Sweden, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	To see if oxytocin lowers satiety	To perform a drinking satiety test twice. Once with oxytocin and once with saline. Then examine whether oxytocin decreases satiety compared to saline	2h	No
Primary	Satiety	The investigator want to examine whether oxytocin leads to lower satiety scores after intake of the same volume of nutrient	2 h	No