VDR SNPs & 25OHD Correlated With Dyslipidemia

Dyslipidemias Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04707612
• Other study ID #: QLS2015
• Status: Completed
• Start date: July 1, 2013
• Est. completion date: October 31, 2016

Study information

• Verified date: January 2021
• Source: Shenzhen Center for Chronic Disease Control
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The project was aimed to explore the associations of single nucleotide polymorphisms (SNPs) of vitamin D receptor gene with specific circulating lipids in adult Chinese. The circulating 25-hydroxyvitamin D concentration was also tested to explore its interactions with SNPs in the associations.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 1987
• Est. completion date: October 31, 2016
• Est. primary completion date: January 31, 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 81 Years

Eligibility

Inclusion Criteria:

• 1) = 20 years old Han Chinese;

• 2) living in Shenzhen for > 2 years;

• 3) free of liver diseases, renal diseases, and any cancers in the past 6 months; and

• 4) not in pregnancy for women.

Exclusion Criteria:

• 1) had severe organic diseases,

• 2) had acute infection symptoms, allergic diseases, and malignant tumors,

• 3) had a family history of genetic diseases,

• 4) took VD supplements in the past 6 months,

• 5) took medicines to control lipid levels within 12 hours, or

• 6) took diuretics, did strenuous exercise, or overate within 24 hours before the test.

Related Conditions & MeSH terms

• Dyslipidemias
• Single Nucleotide Polymorphism

Intervention

Other:
• No intervention.
No intervention.

Locations

Country	Name	City	State
China	Shenzhen Center for Chronic Disease Control	Shenzhen	Guangdong

Sponsors (2)

Lead Sponsor	Collaborator
Shenzhen Center for Chronic Disease Control	Sun Yat-sen University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	SNPs of VDR	Polymorphisms of vitamin D receptor gene: Cdx2, Fok1, Apa1, and Taq1	6 months
Primary	lipid profiles	Serum concentrations of TG, TC, LDLC, and HDLC	6 months
Primary	25OHD	Plasma 25-hydroxyvitamin D concentration	6 months