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Study to Investigate Safety, Tolerability, PK and PD Response of SLN360 in Subjects With Elevated Lipoprotein(a)

Dyslipidemias Clinical Trial

Official title:
A Randomised, Double-blind, Placebo Controlled, First-in-human Study to Investigate the Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Response of SLN360 in Subjects With Elevated Lipoprotein(a)

Clinical Trial Summary

This study will investigate the safety and tolerability of SLN360 in patients with elevated Lp(a).

Clinical Trial Description

This first-in-human (FIH) study will investigate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of SLN360 after single ascending s.c. doses and multiple doses in healthy male and female subjects. Up to 9 cohorts of 88 patients with elevated Lp(a) will be enrolled. Each patient will receive single or multiple doses of SLN360 or placebo given by subcutaneous (s.c) injection. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04606602
Study type Interventional
Source Silence Therapeutics plc
Contact
Status Completed
Phase Phase 1
Start date November 18, 2020
Completion date August 23, 2023
View Details
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