Dyslipidemia Clinical Trial
Official title:
The Effects of Resveratrol on Serum Apolipoprotein A-I Concentrations in Men and Women With Low HDL-cholesterol Concentrations
Although much effort has been done to lower LDL-cholesterol concentrations, there is still a
substantial risk for cardiovascular disease (CVD). Another strategy to lower the risk for
CVD is elevating the HDL-cholesterol (HDL-C). Both in vitro and in vivo studies showed that
elevating HDL-C or apolipoprotein A-I (Apo A-I) levels protect against CVD. However, despite
many initiatives, no new widely applicable intervention strategies with proven efficacy have
been developed.
Epidemiologic studies have shown that a higher polyphenol intake is associated with a lower
risk for CVD. Resveratrol, a polyphenol, could, through several beneficial mechanisms, exert
a positive effect on formation of atherosclerotic plaques and thus on developing CVD. It has
been shown in animals that resveratrol elevates PPAR-alpha activity. This may lead to
elevated apo A-I and HDL-C levels in the blood. However, these effects are not shown in
human intervention studies.
n/a
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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