Dyslipidemia Clinical Trial
Official title:
Effect of Plant Sterols Esterified to Fish Oil Fatty Acids on Plasma Lipid Levels in Healthy, Hyperlipidemic Subjects
The purpose of this study is to determine whether plant sterols esterified to fish oil fatty acids in a fish oil matrix improve the lipid profile, predominantly LDL-cholesterol and TG concentrations in healthy hyperlipidemic subjects.
Phytosterols and omega-3 fatty acids (n-3) are natural food ingredients with potential
cardiovascular (CVD) benefits. Phytosterols inhibit dietary cholesterol absorption and
biliary cholesterol re-absorption, thereby reducing blood cholesterol levels, while
consumption of n-3 is associated with a significant reduction in plasma triglyceride
concentrations. Furthermore, n-3 may also beneficially modify a number of other risk factors
of CHD, like anti-inflammatory and anti-thrombotic.
The primary objective of this study is to determine whether plant sterols esterified to fish
oil fatty acids in a fish oil matrix improve the lipid profile, predominantly
LDL-cholesterol and TG concentrations in healthy hyperlipidemic subjects. In addition the
supplement efficacy to lower other CVD-related risk factors of healthy will be evaluated.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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