Dyslipidaemias Clinical Trial
Official title:
A Multi-center, Three-staged, Randomized, Parallel Group, Sequential, Double-blind, fenofibrate-and Placebo-controlled Dose-response Evaluation of the Safety, Tolerability, and Effects on Plasma HDLc and TG of Eight Weeks Treatment With 1µg to 20µg Daily Doses of GW590735 in Otherwise Healthy Subjects With Low HDLc, Mildly to Moderately Elevated TG, and Normal LDLc
An eight week comparison of the investigational drug GW590735, placebo, and the marketed drug fenofibrate intended to increase the levels of "good cholesterol" and decrease levels of "bad cholesterol" in healthy patients with low levels of good cholesterol and high levels of bad cholesterol.
A multi-center, three-staged, randomized, parallel group, sequential, double-blind, fenofibrate-and placebo-controlled dose-response evaluation of the safety, tolerability, and effects on plasma HDLc and TG of eight weeks treatment with 1µg to 20µg daily doses of GW590735 in otherwise healthy subjects with low HDLc, mildly to moderately elevated TG, and normal LDLc ;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT00783549 -
A Study in Healthy Volunteers of Single Doses of Orally Administered Investigational Product to Investigate Safety, Tolerability, and Pharmacokinecs.
|
Phase 1 | |
| Completed |
NCT01218204 -
A Study to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Administering Multiple Oral Doses of GSK1292263 Alone and With Atorvastatin
|
Phase 2 | |
| Completed |
NCT00551694 -
A Second Study to Determine the Effect of GSK256073A on HVTs
|
Phase 1 | |
| Completed |
NCT00808093 -
Repeat Dose Food Effect Study of GSK256073F in Healthy Adult Subjects
|
Phase 1 | |
| Completed |
NCT00488449 -
Study Of Pharmacokinetics and Pharmacodynamics Effects Of GSK256073A On Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT00903617 -
Study to Test GSK256073 in Patients With Dyslipidemia
|
Phase 2 | |
| Completed |
NCT00474864 -
Study To Evaluate The Effects Of GW856553 On Endothelial Function/Vascular Compliance In Subjects With Dyslipidaemia.
|
Phase 2 | |
| Completed |
NCT00608699 -
A Study To See If GSK256073A Can Block Niacin-Induced Flushing In Healthy Volunteers
|
Phase 1 | |
| Terminated |
NCT00318617 -
Effect Of GW501516X On How The Heart Obtains And Uses Energy
|
N/A | |
| Completed |
NCT00388180 -
An Exploratory Study To Look At The Effect Of Two Investigational Drugs On Body Fat And Inflammation
|
N/A | |
| Completed |
NCT00158899 -
GW501516 In Subjects Who Have Low Level Of High-Density Lipoprotein Cholesterol
|
Phase 2 |