Dopaminergic Enhancement of Learning and Memory in Healthy Adults and Patients With Dyslexia

Dyslexia Clinical Trial

Official title: Dopaminergic Enhancement of Learning and Memory (LL_001, Project on Dyslexia)

Status Recruiting

Clinical Trial Summary

This study aims to determine whether levodopa, in combination with a high frequency training of (grammatical) rules, is effective in boosting learning success in healthy subjects and whether this kind of training in combination with levodopa improves reading and spelling abilities of patients with dyslexia.

Clinical Trial Description

Prior work by our group shows that d-amphetamine and the dopamine precursor levodopa markedly improve word learning success in healthy subjects. In this randomized, placebo-controlled, double-blind trial, we probe whether daily administration of levodopa, coupled with a training of grammatical rules, improves the training success in healthy adults as compared to placebo administration. In the second step of this study, patients with dyslexia will be trained with the identical protocol. We postulate that the combination of intensive training in language rules and levodopa improves the reading, writing, and spelling abilities of patients with dyslexia. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

• Dyslexia

• NCT number: NCT00111371
• Study type: Interventional
• Source: University Hospital Muenster
• Contact: Stefan Knecht, MD
• Phone: +49-251-83
• Email: knecht@uni-muenster.de
• Status: Recruiting
• Phase: Phase 4
• Start date: January 2005
• Completion date: October 2015