Dysbiosis Clinical Trial
Official title:
Interactions Between Skincare Product Ingredients and the Skin Microbiome
This is a study of the influence of skincare products containing chemicals such as parabens and phthalates on the skin microbiome.
Skin serves as a critical barrier between our bodies and the environment and the locus for a
diverse and active microbial community. The composition and metabolic activity of the
microbial community on the skin is presumably influenced by the local chemical environment,
which includes natural skin lipids (e.g., squalene and sapienic acid), components of personal
care products applied directly to skin, and semi-volatile organic compounds (SVOCs) that
reach the skin through gas phase absorption, dust deposition, and direct contact with
surfaces. Common semi-volatile ingredients in skin care products include phthalates,
parabens, and UV blocking compounds (e.g., oxybenzone, octocrylene or homosalate).
The investigators have recently demonstrated a method of collecting chemicals from areas of
skin with infrequent direct dermal contact using alcohol wipes to assess passive air to skin
partitioning of both target and nontarget compounds (Garrido et al., in review).
Low-volatility reaction products can accumulate in skin oils and act as skin irritants, with
the potential of being absorbed into the bloodstream. With methods developed for chemical and
microbiome sampling, the overall goal of the proposed research is to develop an understanding
of the two-way interaction between organic chemicals on the skin and the composition of the
skin microbiome.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05560087 -
Association of PeRiODontal Disease and gUt Microbiome With Coronary artEry Disease (PRODUCE Study)
|
||
| Recruiting |
NCT05288790 -
Microbiome Metabolites and Alcohol in HIV to Reduce CVD RCT
|
Phase 2 | |
| Completed |
NCT05575050 -
Impact of Teeth Brushing in Ventilated COVID-19 Patients.
|
N/A | |
| Completed |
NCT06423586 -
Effect of Lecithin-based Curcuma and Boswellia on Post-acute COVID-19 IBS
|
N/A | |
| Completed |
NCT04079218 -
Accelerated Genital Tract Aging in HIV: Estradiol Clinical Trial
|
Phase 4 | |
| Active, not recruiting |
NCT03554278 -
Alteration of Stool Microbiota in Preterm Infants With Anemia
|
||
| Completed |
NCT03659240 -
Prebiotic Effects of a Polyphenol-rich Food Product
|
N/A | |
| Completed |
NCT04118049 -
Vaginal Probiotics and Pessaries and Their Impact on the Vaginal Microenvironment
|
N/A | |
| Enrolling by invitation |
NCT06122636 -
Efficacy of a Probiotic and Microbiological Analysis on Oral Complications Induced by Antineoplastic Therapies in Patients With HNC
|
N/A | |
| Recruiting |
NCT04200521 -
The Effect of Bariatric Procedures on Gut Microbiota in Obese Individuals in United Arab Emirates and Lebanon
|
||
| Completed |
NCT03523403 -
Obesity-related Health Benefits of Apples
|
N/A | |
| Recruiting |
NCT05176535 -
Determination of Vaginal Colonization and the Effect of an Oral Probiotic (PROSALVAG)
|
N/A | |
| Recruiting |
NCT06005298 -
Alcohol Misuse, Gut Microbial Dysbiosis and PrEP Care Continuum: Application and Efficacy of SBIRT Intervention
|
N/A | |
| Completed |
NCT03675048 -
Lactobacillus Reuteri DSM 17938 in Gut Microbiota Development in Infant Born by Caesarean Section
|
N/A | |
| Completed |
NCT03043300 -
A Pilot Study Assessing Intestinal Microbiota Diversification and Changes After Travel to South(East) Asia From the US
|
||
| Recruiting |
NCT05790564 -
Almonds to Improve Gut Health and Decrease Inflammation
|
N/A | |
| Completed |
NCT04561284 -
Carbohydrate-induced Resilience of the Gut Microbiome After Antibiotics Use
|
N/A | |
| Enrolling by invitation |
NCT04527055 -
The Efficacy of 10-day and 14-day Bismuth-based Quadruple Therapy in First-line H. Pylori Eradication
|
Phase 4 | |
| Recruiting |
NCT05622721 -
REMBRANDT: REcovery of the MicroBiome fRom Antibiotics for Dental implanTs
|
||
| Recruiting |
NCT05632497 -
Alteration of Symbiosis Intestinal Microbiota on Patients With Anorexia Nervosa
|