Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project

Duration of Hospitalization Clinical Trial

Official title:

Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT01379664
• Other study ID #: 11-440
• Status: Recruiting
• Phase: N/A
• First received: June 17, 2011
• Last updated: March 14, 2013
• Start date: July 2011
• Est. completion date: December 2013

Study information

• Verified date: March 2013
• Source: The Cleveland Clinic
• Contact: Gretchen Upton
• Phone: 216-444-3289
• Email: uptong[@]ccf.org
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Preliminary retrospective data suggest that the relatively soluble but inexpensive volatile anesthesia isoflurane prolongs the duration of hospitalization compared to the less soluble but more expensive anesthetic sevoflurane. Even a small reduction in the duration of hospitalization would easily compensate for the modest additional cost of sevoflurane. The investigators therefore propose to test the primary hypothesis that duration of hospitalization is longer with isoflurane than sevoflurane.

The investigators will also test the secondary hypotheses that: 1) pain scores are greater in patients recovering from isoflurane than sevoflurane anesthesia; and, 2) opioid consumption is greater after isoflurane than sevoflurane anesthesia. All statistical analyses will be adjusted for age, gender, race, baseline risk, 9 and procedure.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 4150
• Est. completion date: December 2013
• Est. primary completion date: July 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Must have surgery in G operating room suite

Study Design

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Health Services Research

Related Conditions & MeSH terms

• Duration of Hospitalization

Intervention

Drug:
• Isoflurane
Isoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist
• Sevoflurane
Sevoflurane is administered to patient during surgery as it would normally be administered by the attending anesthesiologist

Locations

Country	Name	City	State
United States	Cleveland Clinic	Cleveland	Ohio

Sponsors (1)

Lead Sponsor	Collaborator
The Cleveland Clinic

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Hospital Length of Stay		participants will be followed for the duration of hospital stay, an expected average of 3 days	No
Secondary	Pain scores	pain scores are greater in patients recovering from isoflurane than sevoflurane anesthesia	up to 3 days after surgery	No
Secondary	opiod consumption	opioid consumption is greater after isoflurane than sevoflurane anesthesia	up to 3 days after surgery	No