Dupuytren's Disease Clinical Trial
Official title:
Registry of Dupuytren's Contracture Treatment Outcomes
Experience with Microbial Collagenase (trade name Xiapex) in Europe currently is limited to
randomised controlled studies.While such studies are essential to determine efficacy and
safety of the product (usually compared to placebo), they provide no information on the
effectiveness of the drug and further aspects of its use (feasibility, tolerability, quality
of life and other patient-related outcomes) in the typical "real-life" setting under
clinical practice conditions.Thus, the present study aims to collect data on the
- Drug utilization of Microbial Collagenase in the hand of physicians, with focus on
feasibility, treatment patterns, and effectiveness in clinical practice
- Context of Microbial Collagenase therapy (setting, patient characteristics, concomitant
treatment, follow-up therapy)
- Effectiveness (with focus on functionality)
- Tolerability
- Patient-related outcomes: patient satisfaction, health-related quality of life
- Physician satisfaction with therapy
- Resource utilization (hospital stays, drug consumption, concomitant medication etc.)
- Long-term outcomes
n/a
Observational Model: Cohort, Time Perspective: Prospective
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05300893 -
Effectiveness of Night Splinting After Percutaneous Needle Fasciotomy in Dupuytren's Contracture
|
N/A | |
| Recruiting |
NCT04122313 -
Post-contracture Release Radiation for Dupuytren's Disease
|
||
| Completed |
NCT01498640 -
Retreatment of Recurrent Dupuytren's Contractures
|
Phase 4 | |
| Completed |
NCT01450397 -
MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex
|
Phase 4 | |
| Completed |
NCT03180957 -
Repurposing Anti-TNF for Treating Dupuytren's Disease
|
Phase 2 | |
| Completed |
NCT00575458 -
Splinting for Dupuytren's Contracture Release
|
N/A | |
| Completed |
NCT00260429 -
Collagenase in the Treatment of Dupuytrens Disease
|
Phase 3 | |
| Recruiting |
NCT05067764 -
Efficacy of Aponeurectomy on the 2-year Recurrence Rate of Dupuytren's Disease
|
N/A | |
| Completed |
NCT02725528 -
Evaluation of Xiaflex: Trial of Effectivenss iN Dupuytren's
|
Phase 3 | |
| Completed |
NCT02193828 -
Phase 2a Dose-Ranging Study to Evaluate Safety and Effectiveness of AA4500 in Treatment of Dupuytren's Disease Nodules
|
Phase 2 | |
| Completed |
NCT00954746 -
Longterm Observational Study in Subjects Treated With AA4500 in AUX-CC-854, 856, 857, 858 & 859
|
N/A | |
| Completed |
NCT04874870 -
Effectiveness of Splinting After Collagenase Injection
|
Phase 3 | |
| Recruiting |
NCT06263699 -
Goniometry and Goniometric Measurement on Standardised Images in Dupuytren's Disease
|
||
| Not yet recruiting |
NCT02294890 -
Knee Stiffness in Fibrosis Diathesis
|
N/A | |
| Completed |
NCT04669704 -
Effectiveness of a Tele-Rehabilitation Evidence-based Tablet App for Rehabilitation in Traumatic Bone and Soft Injuries of the Hand, Wrist and Fingers.
|
N/A | |
| Recruiting |
NCT05440240 -
Percutaneous Needle Fasciotomy +/- Corticosteroid Injection for Dupuytren's Contracture
|
Phase 4 | |
| Recruiting |
NCT06142929 -
Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence
|
||
| Active, not recruiting |
NCT01446432 -
Validation of Two New Questionnaires for Dupuytren's Disease
|
N/A | |
| Recruiting |
NCT06281509 -
Palmaris Longus Muscle and Dupuytren
|
N/A | |
| Recruiting |
NCT06321991 -
Nodular Shrinking in Dupuytren Disease
|
Phase 2 |