Duodenal Ulcer Clinical Trial
Official title:
A Study to Investigate the Preventive Effect of AG-1749 Against the Recurrence of Gastric and Duodenal Ulcers During Long-term Treatment With Nonsteroid Anti-inflammatory Drug
The purpose of this study is to determine whether AG-1749 (lansoprazole), once daily (QD), is effective in preventing the recurrence of gastric and duodenal ulcers in patients receiving long term treatment with nonsteroid anti-inflammatory drug, compared to gefarnate, twice daily (BID).
In Japan, nonsteroid anti-inflammatory drug is one of common prescribed drugs for patients
as an analgesic antipyretic, treating symptoms of cold, antiphlogistic and management of
pain with rheumatoid arthritis, osteoarthrosis, lumbago. On the other hand, this nonsteroid
anti-inflammatory drug sometimes causes gastric and duodenal ulcers and this ulcer leads to
the gastrointestinal bleeding which may be cause of death.
The purpose of this study is to assess the efficacy of lansoprazole versus gefarnate in
patients with a history of gastric or duodenal ulcers receiving daily nonsteroid
anti-inflammatory medication.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
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