Duchenne Muscular Dystrophy Clinical Trial
Official title:
The Evaluation of Muscle Activation in Climbing up Stairs Activity in Children With Duchenne Muscular Dystrophy
Children with Duchenne Muscular Dystrophy (DMD) have difficulties towards the end of the
ambulatory period, especially in activities that require lower extremity proximal muscle
strength such as walking, climbing stairs, standing up without sitting. Stair climbing /
descending activity is a complex activity that requires joint stability, correct muscle
synergy and timing. When the literature is examined; It has been observed that the
performance of stair climb up and down activity in individuals with neuromuscular disease has
been evaluated with various clinical applications. In recent studies, there are surface
electromyography (EMG) studies evaluating various aspects of stair climbing and descending
activity.
Surface EMG; is a technique for neuromuscular evaluations that is frequently used in both
research and clinical applications, noninvasive, and can be used in areas such as
neurophysiology, sports science and rehabilitation.
Our study was planned to examine the muscle activations in the lower limb muscles involved in
climbing up stairs activity in children with DMD and to compare healthy children with
children with DMD and children with different levels of DMD.
Hypothesis originating from the investigation:
H0: There is no difference in the muscle activations measured by surface electromyography
(EMG) of the involved lower extremity muscles during climbing up stairs activity between
level 1 and level 2-3 children with early DMD.
H1: There is a difference in the muscle activations measured by surface electromyography
(EMG) of the involved lower extremity muscles during climbing up stairs activity between
level 1 and level 2-3 children with early DMD.
H2: There is no difference in the muscle activations measured by surface electromyography
(EMG) of the involved lower extremity muscles during climbing up stairs activity between
children with DMD and healthy children.
H3: There is a difference in the muscle activations measured by surface electromyography
(EMG) of the involved lower extremity muscles during climbing up stairs activity between
children with DMD and healthy children.
In our study, children will be assessed using the surface Electromyography (EMG) device by
using electrodes placed in the relevant lower limb muscles that take part during the stair
climbing activity.
The study included 10 children with DMD levels were 1 and 10 children with DMD levels were
2-3 according to the Brooke Lower Limb Functional Classification scale and 10 healthy
children.
Muscle activation of vastus lateralis, biceps femoris, tibialis anterior and gastrocnemius
medialis muscles will be measured by superficial electromyographic measurement. Muscle
activation according to SENIAM (surface EMG for a non-invasive assessment of muscles) for
will be evaluated.
Stair climbing activity will be performed 3 times and at 1 minute intervals.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05575648 -
Dual Task in Duchenne Muscular Dystrophy
|
N/A | |
| Terminated |
NCT03907072 -
Efficacy and Safety Study of WVE-210201 (Suvodirsen) With Open-label Extension in Ambulatory Patients With Duchenne Muscular Dystrophy
|
Phase 2/Phase 3 | |
| Not yet recruiting |
NCT06450639 -
An Open-label Study to Assess the Efficacy and Safety of Satralizumab in Duchenne Muscular Dystrophy
|
Phase 2 | |
| Completed |
NCT04335942 -
Characterization of the Postural Habits of Wheelchair Users Analysis of the Acceptability of International Recommendations in the Prevention of Pressure Sores Risk by Using a Connected Textile Sensor
|
N/A | |
| Active, not recruiting |
NCT04906460 -
Open-label Study of WVE-N531 in Patients With Duchenne Muscular Dystrophy (FORWARD-53)
|
Phase 1/Phase 2 | |
| Active, not recruiting |
NCT02500381 -
Study of SRP-4045 (Casimersen) and SRP-4053 (Golodirsen) in Participants With Duchenne Muscular Dystrophy (DMD)
|
Phase 3 | |
| Enrolling by invitation |
NCT05967351 -
A Long-term Follow-up Study of Participants Who Received Delandistrogene Moxeparvovec (SRP-9001) in a Previous Clinical Study
|
Phase 3 | |
| Recruiting |
NCT03067831 -
Bone Marrow-Derived Autologous Stem Cells for the Treatment of Duchenne Muscular Dystrophy
|
Phase 1/Phase 2 | |
| Recruiting |
NCT01834040 -
Study Safety and Efficacy of BMMNC for the Patient With Duchenne Muscular Dystrophy
|
Phase 1/Phase 2 | |
| Completed |
NCT02246478 -
A Study of TAS-205 for Duchenne Muscular Dystrophy
|
Phase 1 | |
| Active, not recruiting |
NCT01772043 -
Duchenne Muscular Dystrophy Tissue Bank for Exon Skipping
|
N/A | |
| Terminated |
NCT01168908 -
Revatio for Heart Disease in Duchenne Muscular Dystrophy and Becker Muscular Dystrophy
|
Phase 2 | |
| Completed |
NCT00758225 -
Long-term Safety, Tolerability and Efficacy of Idebenone in Duchenne Muscular Dystrophy (DELPHI Extension)
|
Phase 2 | |
| Completed |
NCT03680365 -
Your Voice; Impact of Duchenne Muscular Dystrophy (DMD) on the Lives of Families
|
||
| Recruiting |
NCT03513367 -
The Validation Process for Confirmation of the French Version of the Pediatric Quality of Life Inventory :PedsQLTM.
|
||
| Recruiting |
NCT05712447 -
Duchenne Muscular Dystrophy Video Assessment Registry
|
||
| Recruiting |
NCT01484678 -
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
|
||
| Completed |
NCT03319030 -
Aerobic Exercise in Boys With Duchenne Muscular Dystrophy (DMD)
|
||
| Terminated |
NCT01753804 -
A Prospective Natural History Study of Progression of Subjects With Duchenne Muscular Dystrophy.
|
N/A | |
| Completed |
NCT02530905 -
Dose-Titration and Open-label Extension Study of SRP-4045 in Advanced Stage Duchenne Muscular Dystrophy (DMD) Patients
|
Phase 1 |