Efficacy of Cevimeline Versus Pilocarpine in the Secretion of Saliva

Status Completed

Clinical Trial Summary

The main objectives were: 1) To determine the efficacy of both cevimeline and pilocarpine in the secretion of saliva in patients with xerostomia, and 2) To compare the side-effects between the treatment for xerostomia with cevimeline and with pilocarpine.

Clinical Trial Description

Pilocarpine is a cholinergic agonist with predominant muscarinic action.As such, it acts at muscarinic-cholinergic receptors found throughout the body and promotes fluid secretion. Due to this, one of the main side-effects of pilocarpine is an increased amount of sweating. Thus, not only are the salivary glands stimulated, but all of the body's exocrine glands' production is heightened. On the other hand, cevimeline is a drug with a high affinity for specific muscarinic receptors (M3) located on lachrymal and salivary gland epithelium. At least in theory, cevimeline will produce less side effects compared with pilocarpine because of the higher affinity for the muscarinic receptors located in the salivary glands. A limited number of human clinical trials in the efficacy of cevimeline and pilocarpine to increase the production of saliva and the side effects have been performed with no conclusive results.

The main purposes of this study were to determine the efficacy of cevimeline and pilocarpine in the secretion of saliva in patients with xerostomia, and to compare the side-effects between these two medications. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01690052
Study type	Interventional
Source	University of Kentucky
Contact
Status	Completed
Phase	N/A
Start date	January 2009
Completion date	July 2010

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT04914208` - Effect of Wearing Face Masks on Salivary Parameters and Halitosis	N/A
Completed	`NCT00601211` - Bioequivalency Study of 5 mg Piolocarpine Tablets Under Fed Conditions	N/A
Completed	`NCT00601874` - Bioequivalency Study of 5 mg Pilocarpine Tablets Under Fasting Conditions	N/A
Completed	`NCT04152642` - A Pilot Study to Assess Dry Mouth Relief After Using an Experimental Mouth Rinse	N/A
Completed	`NCT03215251` - Effectiveness of an Intervention Bundle on Thirst Intensity and Dry Mouth Among Patients in ICUs	N/A
Completed	`NCT04632004` - Questionnaire Regarding the Effect of Wearing Face Masks on Oral Health	N/A
Completed	`NCT05640362` - Efficacy of Natural Enzymes Mouthwash: a Randomised Controlled Trial	N/A
Not yet recruiting	`NCT06412627` - The Effect of Intervention About Dry Mouth and Thirst in Patients With Endotracheal Tube	N/A
Completed	`NCT04986501` - Clinical Evaluation of MucoPEG™ for Xerostomia	N/A
Completed	`NCT04189081` - Improvement of Dry Mouth Sufferers After Using an Experimental Dry Mouth Rinse Compared to a Water Control	N/A
Completed	`NCT05871580` - Effect to the Photobiomodulation in the Burning Mouth Syndrome	N/A
Completed	`NCT06258603` - Oral Care of Intubated Intensive Care Patient	N/A
Completed	`NCT01737307` - Effect of Fluoride Varnish and CPP-ACP on Oral and Salivary Symptoms During Chemotherapy	Phase 2
Completed	`NCT01647737` - Green Tea Lozenges for the Management of Dry Mouth	Phase 1/Phase 2
Active, not recruiting	`NCT03874572` - Allogeneic Mesenchymal Stem Cells for Radiation-induced Hyposalivation and Xerostomia/Dry Mouth	Phase 1
Completed	`NCT03035825` - Efficacy of Oral Moisturizing Jelly on Oral Health and Nutrition in Post-radiotherapy Head and Neck Cancer Patients	N/A
Recruiting	`NCT05964959` - A Mouth Education Program for Dry Mouth	N/A
Withdrawn	`NCT02123147` - Examining the Immunological Process of Autoimmune Patients	N/A
Completed	`NCT01885065` - Efficacy of Novel Edible Gel-based Artificial Saliva in Cancer Patients	N/A
Completed	`NCT03281486` - "Hyaluronan" Formulation for Type 2 Diabetic Patients With Dry Mouth	N/A