Dry Eye Clinical Trial
Official title:
Acupuncture for Dry Eye: a Multicenter Randomized Controlled Trial With Active Comparison Intervention (Artificial Tear Drop) Using a Mixed Method Approach
The purpose of this study is to assess whether acupuncture is more effective than artificial tear drop in the treatment of dry eye.
Dry eye is one of the common diseases in ophthalmology. It affects not only patients' daily
activities such as reading, carrying out professional work, using the computer, watching
television, and driving, but also bodily health conditions such as bodily pain, discomfort
and lower energy and vitality.
Currently, artificial tears are easily subscribed or used in the shape of OTC drugs.
However, preservatives in artificial tears may exacerbate ocular surface inflammation and
the safety of anti-inflammatory treatment is not well established.
Acupuncture, one of the most popular CAM interventions, showed some favourable effects over
artificial tears for dry eye in several randomised controlled trials (RCTs). The evidence
obtained from these trials is quite limited because all of these RCTs were conducted under
high risk of biases. Therefore, well-designed RCTs are needed to establish the efficacy of
acupuncture for dry eye.
In a clinical trial, cost-effectiveness and qualitative researches can be carried out
parallely. Through this kind of mixed method approaches, various compartments, consisting
acupuncture treatment effects are able to be revealed totally.
In this context, the investigators designed a multi-center randomized controlled trial,
comparing acupuncture treatment and artificial tear drop with immunoassay for the change of
tear cytokine concentration, cost effectiveness study and qualitative research in a mixed
method approach.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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