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Dry Eye clinical trials

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NCT ID: NCT05923528 Not yet recruiting - Dry Eye Clinical Trials

Comparison of Non-pharmaceutical Treatments for Evaporative Dry Eye

Start date: November 1, 2023
Phase: N/A
Study type: Interventional

The lipid layer of the tear film is critical to maintaining the integrity of the tear film and deficiency in the tear film lipid layer (TFLL) is the cause of evaporative dry eye (EDE) in approximately 80% of dry eye disease patients, resulting in excessive evaporation (so-called hyperevaporative dry eye). This study protocol was designed to assess and compare the effects of intense pulsed light (IPL), heated eye mask (HEM), vectored thermal pulsation system (VTPS), and eyelid massage device (EMD) for improving signs and symptoms of EDE. EDE patients will be randomly divided into IPL, HEM, VTPS, and EMD groups and will be followed up for four weeks. The primary outcome measure will be non-invasive tear breakup time (NITBUT). The secondary outcome measures will include, tear film lipid layer score (TFLL), meibomian gland function and secretion quality change from baseline conjunctival and cornea staining (CFS) with fluorescein and lissamine, tear meniscus height (TMH), conjunctival hyperemia (RS score) and ocular surface disease index (OSDI) questionnaire. Additionally, adverse events also were monitored and documented.

NCT ID: NCT05720754 Not yet recruiting - Dry Eye Clinical Trials

Temperature on Evaporative Dry Eye

Start date: April 2, 2023
Phase: N/A
Study type: Interventional

Ocular surface temperature of a normal person is around 34.6 degree centigrade. After instilling the eye drop, depending on the temperature of the eye drop and the ocular surface, the ocular surface temperature will temporally increase or decrease sightly. Warm feeling will make blood vessels dilated and more blood will pass through to bring more blood flow out of our body to the heated area of the body and makes cells more permeable. Therefore, heating the ocular surface with heated eye mask after instilling artificial tears has the possibility to improve drug permeability on the ocular surface.

NCT ID: NCT05632887 Not yet recruiting - Dry Eye Clinical Trials

The Effect of Eyeliner on Tear Composition, Tear Secretion and Tear Film Stability.

Start date: February 15, 2023
Phase:
Study type: Observational

Eyeliner is one of the most common eye cosmetics. The main ingredients are titanium oxide, pigment, grease and preservative. The user will apply the eyeliner to the eyelid and eyelash. With the blinking again and again, the components of the eyeliner may enter the tear film and continue to act on the eye surface. Therefore, the investigators suspect that the use of eyeliner may be an important factor leading to dry eye disease. In order to explore the relationship between the use of eyeliner and dry eye disease, the investigators plan to collect eye surface characteristic data of the two groups of people who use eyeliner and who do not use it.Then use Raman analysis to explore whether the use of eyeliner will lead to changes in tear composition.The investigators intend to analyze the difference of tear composition between the two groups to understand the relationship between the change of tear composition and tear film stability.So that the investigators can identify the risk factors of dry eye disease, and provide basis for prevention and early treatment.

NCT ID: NCT05320172 Not yet recruiting - Dry Eye Clinical Trials

Platelet Rich Plasma in Corneal Surface Diseases

Start date: June 2023
Phase: Phase 3
Study type: Interventional

The Aim of the study is to evaluate the efficacy of platelet rich plasma eye drops in the management of different corneal surface disorders. PRP is a blood sample with a concentrated platelet count, and numerous growth factors that are associated with conjunctival and corneal wound healing process. which is an important advantage over other products. PRP eye drops recently are proving to be an effective and potent therapeutic approach to promote corneal wound re-epithelization and promote ocular surface regeneration in different pathological conditions.

NCT ID: NCT05191771 Not yet recruiting - Dry Eye Clinical Trials

Evaluation of Neovis® Total Multi Versus Systane® Balance on Ocular Dryness Associated With Meibomian Gland Dysfunction

Start date: January 2022
Phase: N/A
Study type: Interventional

This study is a multicentric, comparative, randomized, investigator-blinded, in parallel groups study to demonstrate the non-inferiority of Neovis® Total Multi in comparison with Systane® Balance, in terms of improvement of stability of Tear film in patients with eye dryness associated to meibomian gland dysfunction, after 28 days of treatment.

NCT ID: NCT05056012 Not yet recruiting - Dry Eye Clinical Trials

Penn SICCA Follow-up Study

PSFS
Start date: July 2024
Phase:
Study type: Observational

This study will involve the collection of follow-up data for patients who previously participated in the Sjogren's International Clinical Collaborative Alliance (SICCA) study at the University of Pennsylvania. Clinical data and specimens will be collected from subjects with objective evidence of dry eye who were or were not diagnosed with Sjogren's syndrome at the time of their initial participation in the SICCA study. Specimens will be collected from participants which will include tears, saliva, whole blood, serum, DNA and possible labial minor salivary gland biopsies when indicated. All individuals will participate in a standard evaluation protocol including an oral, ocular and physical examination, objective tests for dry eyes and dry mouth and, whenever necessary, a labial minor salivary gland biopsy. The biopsy requirement is waived for those who have already had positive lip biopsies in the past.

NCT ID: NCT04411615 Not yet recruiting - Dry Eye Clinical Trials

Effect of Re-esterified Triglyceride (rTG) Form Omega-3 Supplements on Dry Eye Following Cataract Surgery

Start date: July 1, 2020
Phase: N/A
Study type: Interventional

To evaluate the clinical outcomes of the systemic re-esterified triglyceride (rTG) form of omega-3 fatty acids in patients with dry eye symptoms after cataract surgery

NCT ID: NCT04131335 Not yet recruiting - Dry Eye Clinical Trials

Use of Prophylactic Lubricating Drops After Cataract Surgery

Start date: October 14, 2019
Phase: N/A
Study type: Interventional

This is a randomised controlled trial to assess the use of prophylactic lubricant eye-drops for 6 weeks following uncomplicated, routine cataract surgery to improve patient satisfaction and symptoms of dry eye, compared to controls.

NCT ID: NCT03769324 Not yet recruiting - Dry Eye Clinical Trials

Validation of Osmolarity System: Clinical Usability Study

Start date: September 15, 2019
Phase:
Study type: Observational

Confirmatory trial to validate usability of a new portable osmolarity testing device.

NCT ID: NCT03645850 Not yet recruiting - Dry Eye Clinical Trials

Evaluation of Efficacy and Safety of Vismed Gel Multi 0.3% Versus Vismed Multi 0.18% on Treatment of Ocular Dryness

Start date: September 1, 2018
Phase: N/A
Study type: Interventional

This study is a multicentric, comparative, randomized, investigator-blinded, parallel group study to demonstrate the non-inferiority of Vismed® Gel Multi 0.3% in comparison with Vismed® Multi 0.18% in terms of cornea and conjunctiva staining (Oxford score) on patients with moderate to severe ocular dryness, after 35 days of treatment.