Dry Eye Syndromes Clinical Trial
Official title:
Comparison of Evaporimetry With the Established Methods of Tear Film Measurement
Purpose:
To establish whether there is a correlation between dry eye symptoms, age and gender, a
difference in symptom intensity in different times of the day, which test (Schirmer or TBUT)
better correlates with dry eye symptoms, whether it is possible to reliably use cheap, easy
to use hygrometer in everyday clinical setting, and finally whether there is statistically
significant correlation between applied tests (TBUT, Schirmer and evaporimetry).
Methods:
Subjects: 45 in group without dry eye related symptoms, and 45 in group with symptoms.
Examination included structured case history (questionnaire), slit lamp examination with
fluorescein staining, periocular evaporimetry, TBUT test and Schirmer test.
Purpose:
The purpose of this study was to establish whether there is a correlation between dry eye
symptoms, age and gender, any difference in symptom intensity in different times of the day,
which test (Schirmer or TBUT) better correlates with dry eye symptoms, whether it is
possible to reliably use cheap, easy to use hygrometer in everyday clinical setting, and,
finally, whether there is statistically significant correlation between applied tests (TBUT,
Schirmer and evaporimetry).
Methods:
Subjects were divided in two groups: 45 in group without dry eye related symptoms, and 45 in
group with symptoms.
Examination was performed in the following sequence:
1. structured case history (questionnaire),
2. evaporimetry
3. slit lamp examination with fluorescein staining,
4. TBUT test and
5. Schirmer test I (without anesthetic, closed eyes)
Case history consisted of the following questions:irritation more pronounced on wind?
irritation during reading and/or watching TV or computer? irritation more pronounced during
winter? gritty sensation in the eyes? irritation more pronounced in the morning or evening?
All answers, except to the last question, were graded from 0 (no complaints) to 3 (severe).
Evaporimetry was performed using commercially available hygrometer from HYGROTEC
(Titisee-Neustadt, Germany), installed in swimming goggles with its front part sawn off.
First measurement was performed by measuring for 5 minutes with eyes closed. Second
measurement also lasted 5 minutes, with eyes kept open, normal blinking, and with subject
fixating at one point in distance, with no eye movements.
Measured parameters included:
basal φ (%): relative environment humidity before measurement basal T: environment
temperature before measurement closed eye φ (%): relative humidity in front of closed eye
open eye φ (%): relative humidity in front of open eye C/O: ratio of φ (%) closed/open eye
;
N/A
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT04425551 -
Effect of Micropulse Laser on Dry Eye Disease Due to Meibomian Gland Dysfunction
|
N/A | |
Not yet recruiting |
NCT06379685 -
Study to Evaluate the Safety and Tolerability of PRO-190 Ophthalmic Solution Compared to Systane Ultra® on the Ocular Surface.
|
Phase 1 | |
Recruiting |
NCT04701086 -
3 Month Study of Cationorm Pro Versus Vismed in Adults With Dry Eye Disease Related to Keratitis or Keratoconjunctivitis
|
N/A | |
Active, not recruiting |
NCT03697876 -
Safety and Tolerability of the Ophthalmic Gel PRO-165 Versus Artelac® Nightime Gel
|
Phase 1 | |
Completed |
NCT02910713 -
Evaluation of Dry Eye Symptoms in CAE With Application of Intranasal Neurostimulation
|
N/A | |
Terminated |
NCT02815293 -
Topical Ophthalmic AGN-195263 for the Treatment of Evaporative Dry Eye
|
Phase 3 | |
Completed |
NCT04104997 -
A Clinical Trial to Evaluate the Safety, Tolerability and Pharmacokinetic Characteristics of GLH8NDE After Single and Mutiple Ocular Administrations in Healthy Korean and Caucasian Volunteers
|
Phase 1 | |
Recruiting |
NCT02595606 -
0.3% Sodium Hyaluronate in the Treatment of Dry Eye of Diabetic Patients
|
Phase 4 | |
Completed |
NCT01711424 -
An Observational Study of OPTIVE PLUS® for the Treatment of Dry Eye Disease
|
N/A | |
Completed |
NCT01202747 -
Evaluation of Screening Methods for Treatment of Meibomian Gland Dysfunction
|
Phase 2/Phase 3 | |
Completed |
NCT01015209 -
Safety and Tolerability of Chitosan-N-acetylcysteine Eye Drops in Healthy Young Volunteers
|
Phase 1 | |
Completed |
NCT00969280 -
Acupuncture for Dry Eye Syndrome
|
Phase 3 | |
Completed |
NCT00756678 -
Efficacy and Acceptability of Two Lubricant Eye Drops
|
Phase 4 | |
Completed |
NCT00739713 -
Effects of Sea Buckthorn Oil on Dry Eye
|
N/A | |
Completed |
NCT00349440 -
Efficacy of Cyclosporine for the Prevention and Treatment of Dry Eye Symptoms Following LASIK or Photorefractive Keratectomy
|
Phase 4 | |
Completed |
NCT00370747 -
Efficacy and Safety Study for Ecabet Ophthalmic Solution for Treating Dry Eye Syndrome
|
Phase 2 | |
Completed |
NCT05162261 -
to Evaluate the Effectiveness and Safety of the Tixel® , VS LipiFlow® in the Treatment of Meibomian Gland Dysfunction
|
N/A | |
Completed |
NCT02871440 -
A Two Comparator, Controlled Phase 3 Study in Patients With and Without Evaporative Dry Eye
|
Phase 3 | |
Completed |
NCT05042960 -
Computer Screen Properties Study
|
N/A | |
Not yet recruiting |
NCT05990712 -
The Effect of a Pre-cataract Surgical Ocular Hygiene Regime on Microbial Load, Tear Osmolarity, Dry Eye, and Inflammatory Markers
|
Phase 4 |