Dry Eye Syndrome Clinical Trial
Official title:
Assessment of Tear Film Thickness by Optical Coherence Tomography in Healthy Subjects and Subjects With Dry Eye Disease
Dry eye syndrome (DES) is a highly prevalent ocular condition with severe consequences for
the patients reaching from ocular discomfort in its simplest form up to visual impairment
and corneal ulceration in severe cases. Data from epidemiological studies indicate that DES
is a common disease, especially in the elderly population, affecting up to 20% of adults
aged 45 years or older. Topical lubricants are a mainstay of therapy, but data on its effect
on tear film thickness and the corneal residence time are lacking.
Recently, a new objective method for assessment of tear film thickness by optical coherence
tomography has been developed. The present study aims to investigate the corneal residence
time of an established topical lubricant compared to placebo in patients with DES and
healthy controls.
n/a
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Basic Science
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