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Dry Eye Disease clinical trials

View clinical trials related to Dry Eye Disease.

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NCT ID: NCT05187533 Recruiting - Dry Eye Disease Clinical Trials

Sphenopalatine Ganglion Stimulation for Ocular and Oral Dryness

Start date: January 15, 2022
Phase: N/A
Study type: Interventional

Dry Eye Disease (DED) is a multifactorial pathology characterized by inflammation of the lacrimal functional unit that develops in ocular surface pathology, severely affecting patients quality of life. The core of the treatment relies at present in antinflammatory topical therapies, which are still scarce. The investigators hypothesize that osteopathy-based techniques may help these patients by influencing the central involvement regarding parasympathetic innervation of tear and saliva-secreting glands. The aim of this osteopathic treatment protocol is to release the involved structures in the tear-secreting system innervation, such as the sphenopalatine ganglion. In addition, this ganglion innervates the minor salivary glands, therefore it is intended to help patients suffering from xerostomia. The hypothesis then is that a systemic protocol treatment can help balance both parts of the vegetative nervous system (sympathetic and parasympathetic) with the objective of increasing the secretion of tear and saliva in patients with ocular and oral dryness (DED and xerostomia, respectively), thus improving their clinical situation. This osteopathic protocol does not have the potential to cause adverse effects. The main objective is to analyze the efficacy of this protocol application in terms of improving symptoms and signs of ocular and oral dryness, tear film quality and inflammation molecule levels in tears and saliva.

NCT ID: NCT04946721 Recruiting - Dry Eye Disease Clinical Trials

2177GCCC:ID'Ing tx Targets and Biomarkers for Ocular Surface Disease in Pt w/ oGVHD

Start date: April 27, 2022
Phase:
Study type: Observational

Evaluate and study the immunologic changes to the ocular surface in cancer patients.

NCT ID: NCT04785261 Recruiting - Dry Eye Clinical Trials

Effect of Traditional Chinese Medicine on Basic Tear Secretion and Tear Cytokines in Patients With Dry Eye Disease

Start date: March 16, 2021
Phase: Phase 2
Study type: Interventional

This is a single center, randomized, single-blind, controlled pilot study of CJDHW plus JWXYS as a complementary therapy to treat dry eye disease during a 12-week period. The investigators intend to enroll 60 subjects aged between 20 and 75 years old (treatment group(N=30); controlled group(N=30)). Treatment group will be treated with artificial tears combined with TCM, while control group will use artificial tears only. The aim of this study is to explore the efficacy of TCM for dry eye disease.

NCT ID: NCT04658238 Recruiting - Dry Eye Disease Clinical Trials

Ocular Microbiome and Immune System in Dry Eyes

Start date: October 1, 2020
Phase:
Study type: Observational

The primary objectives of this study are the characterization of the ocular microbiome as well as of the local immune system in participants with and without dry eye disease. Secondary objectives are the identification of differences in the ocular microbiome as well as in the immune system between participants with and without dry eye disease to ultimately find associations between the ocular microbiome and the immune system in dry eye disease.

NCT ID: NCT04235400 Recruiting - Dry Eye Disease Clinical Trials

Multimodal Screening of Dry Eye Disease

MAOS-S
Start date: January 28, 2021
Phase:
Study type: Observational

Two methods allow to evaluate tear breakup time (BUT): without prior dye instillation (No Dye BreakUp Time NDBUT) or after fluorescein instilation (FBUT). The interconnections between those two values are unknown