Clinical Trial Details
— Status: Completed
Administrative data
NCT number |
NCT03839186 |
Other study ID # |
XYHMZK PG 2000 |
Secondary ID |
|
Status |
Completed |
Phase |
|
First received |
|
Last updated |
|
Start date |
August 2016 |
Est. completion date |
April 2019 |
Study information
Verified date |
March 2018 |
Source |
Xiangya Hospital of Central South University |
Contact |
n/a |
Is FDA regulated |
No |
Health authority |
|
Study type |
Observational
|
Clinical Trial Summary
This study intends to study the effects of anesthetics on Circulatory Function Genomics and
find the anesthetic effects in pharmacodynamics, pharmacokinetics, drug receptor or target
DNA level differences, further guiding individual treatment in clinic, promoting the
development of precision the medicine.The anesthesia medication during perioperative period
is more and more accurate,reasonable and safe, so as to improve the satisfaction of the
patients and their families in the perioperative period, to ensure the safety of patients.
Description:
This study is a non traumatic and non intervention study, and will use a large sample of
clinical research, the number of subjects to be enrolled in the study group are 200 cases.
The basic information of the study was included in the study before the operation. During the
operation, the investigators need a collection of participants's arterial blood and monitor
the hemodynamic index and anesthesia depth by bispectral index(BIS) . Further moreļ¼the
investigators will follow up the participants' condition after operation.Dividing the
patients into different groups according to their clinical features.The relationship between
vital signs and the depth of anesthesia was analyzed and compared between different
groups.Blood samples collected during the operation were detected by gene test. Comparing the
results of genetic testing and clinical data analysis, then the investigators will find the
differences in the expression of the gene polymorphisms of anesthetic drugs in the
circulating function.