Drug-induced Liver Injury Clinical Trial
Official title:
A Multi-center, Prospective, Non-interventional Cohort Study on Drug Induced Liver Injury in Mainland China
This is a multi-center, prospective, non-interventional cohort study .
Its primary objectives are:
1. assess DILI patients' clinical characteristics, disease progression and influencing
factors in clinical practice;
2. learn about suspected drug caused DILI,rechallenging, liver biochemical abnormalities
mode, etc.
The main purpose of this study is to understand patients with DILI clinical outcome and
influencing factors in China's second and tertiary general hospitals (including Western
medicine hospital, Chinese medicine hospital andIntegrated traditional Chinese and Western
Medicine Hospital) and vulnerabilities of drug-induced liver injury specialist hospital
(tuberculosis hospital, Pulmonary, etc.) in mainland.
The main purpose
1. assess the DILI patients' clinical outcomes and influencing factors in the real world;
2. learn about suspected drug caused DILI,rechallenging, liver biochemical abnormalities
mode, etc.
Secondary objectives
1. assess the compliance of the DILI practice to the 2015 vision of the DILI guidelines in
china.;
2. evaluate the histological features of DILI patients;
3. assessment DILI characteristics, prognosis and influencing factors in specific
populations(such as the elderly, children with underlying liver disease background,
etc.)
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Recruiting |
NCT05517668 -
Evaluation of the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
|
Phase 2 | |
| Recruiting |
NCT05060289 -
A Prognostic Model for Drug-induced Liver Injury in China
|
||
| Completed |
NCT03092817 -
Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial)
|
Phase 3 | |
| Completed |
NCT03211208 -
Assessing Antibiotic Induced Liver Injury for Stratification of Tuberculosis Patients
|
||
| Not yet recruiting |
NCT02061826 -
Establishment of Drug-induced Liver Injury Databases and Application of Circulating microRNA(miRNA)
|
N/A | |
| Completed |
NCT02182167 -
A Trial Of Intravenous N-Acetylcysteine In The Management Of Antituberculous Drug-Induced Hepatitis
|
Phase 2/Phase 3 | |
| Completed |
NCT03665402 -
A Pharamcogenomic Study for Isoniazid According to NAT2 Polymorphism Status
|
N/A | |
| Not yet recruiting |
NCT03091556 -
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Pill.
|
N/A | |
| Not yet recruiting |
NCT03091244 -
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Capsule.
|
N/A | |
| Not yet recruiting |
NCT03091608 -
Surveillance for Early Liver Injuries Caused by Xianlin Gubao Granule
|
N/A | |
| Not yet recruiting |
NCT03060252 -
Surveillance for Early Liver Injuries Caused by Zhuanggu Guanjie Pill
|
N/A | |
| Not yet recruiting |
NCT03091218 -
Surveillance for Early Liver Injuries Caused by Runzao Zhiyang Capsule.
|
N/A | |
| Completed |
NCT02407964 -
A Retrospective Study on Drug Induced Liver Injury in China
|
N/A | |
| Active, not recruiting |
NCT05144217 -
Impact of Silymarin Dosages to Decrease Drug-induced Elevated Liver Enzymes Compared to Placebo
|
Phase 2/Phase 3 | |
| Completed |
NCT01705041 -
Preliminary Evaluation of a Point-Of-Care Liver Function Test
|
N/A | |
| Recruiting |
NCT02086708 -
Ultrasound Method to Measure Fibrosis of the Liver in Children
|
N/A | |
| Recruiting |
NCT05465642 -
Alterations of Gut Microbiota and Serum Biochemical Markers in DILI Patients
|
||
| Completed |
NCT01434173 -
Risk of Acute Liver Injury in Users of Antimicrobials
|
N/A | |
| Completed |
NCT05532345 -
Discrimination of DILI and AIH by Artificial Intelligence
|
||
| Completed |
NCT03602703 -
Immune Responses in Hepatocellular Carcinoma Patients After Treatment With Direct Acting Antiviral Drugs
|