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Effects of Switching From Racemic Methadone to R-methadone on QTc Intervals — MePhaCard  

Drug Effect Clinical Trial

Official title:
The Study of Potential Normalization of Cardiac Rhythm Following Drug Exchange From Chimeric Methadone to Active Methadone

Clinical Trial Summary

Effects of switching from racemic methadone to R-methadone on serum methadone concentrations and QTc intervals

Clinical Trial Description

Racemic methadone may prolong the QTc interval, which is associated with fatal arrhythmias. In vitro studies have shown that R-methadone has less inhibitory effect than S-methadone on the voltage-gated potassium channel current, and is thus thought to have less effect on the QTc interval. The investigators hypothesized that switching from racemic to R-methadone would reduce the methadone serum concentration and also its effect on the QTc interval. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04254731
Study type Interventional
Source Oslo University Hospital
Contact
Status Active, not recruiting
Phase Phase 4
Start date May 7, 2015
Completion date July 30, 2024
View Details
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