Drug Drug Interaction Clinical Trial
Official title:
A Phase 1, Open Label, Fixed Sequence Study to Evaluate the Effect of BLD-0409 on the Single Dose Pharmacokinetics of a Cocktail of Probe Substrates for CYP450 Enzymes in Healthy Volunteers
A Phase 1, Open Label, Fixed Sequence Study to Evaluate the Effect of BLD-0409 on the Single Dose Pharmacokinetics of a Cocktail of Probe Substrates for CYP450 Enzymes in Healthy Volunteers
This is a single center, open label study designed to determine the effect of BLD-0409 on the PK of probe substrates and to evaluate the safety and tolerability of BLD-0409 administered alone and co-administered with a cocktail of probe substrates (i.e., Geneva cocktail less fexofenadine) in healthy adult volunteers. Geneva Cocktail (Less Fexofenadine): - CYP1A2 Caffeine 50 mg - CYP2C Flurbiprofen 10 mg - CYP2C19 Omeprazole 10 mg - CYP2D6 Dextromethorphan 10 mg - CYP3A4 Midazolam 1 mg - CYP2B6 Bupropion 20 mg ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05574374 -
Drug-drug Interactions Between DWP14012 and DWC202202 in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT04557397 -
Fruquintinib CYP3A Inhibitor and Inducer Study
|
Phase 1 | |
| Completed |
NCT06031454 -
Drug-durg Interaction of Leritrelvir(RAY1216) With Midazolam, Omeprazole, Rosuvastatin, Verapamil, and Rifampin
|
Phase 1 | |
| Completed |
NCT05137600 -
A Drug-Drug Interaction Study Between ATI-2173 and Midazolam or Clarithromycin in Healthy Subjects
|
Phase 1 | |
| Recruiting |
NCT06119958 -
Drug-drug Interactions Between DWC202313 and DWC202314 in Healthy Subjects
|
Phase 1 | |
| Active, not recruiting |
NCT05812404 -
Phase 1 Clinical Trial to Evaluate the Effect of DWP14012 on the Pharmacokinetics of DWC202201 in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT04606537 -
Drug to Drug Interaction Study of KBP-5074 in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT04939467 -
Dedicated Drug-Drug Interaction (DDI) Study in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT04542252 -
Drug-Drug Interaction Study of Intravenous Administration of SyB V-1901 and Cyclosporine in Japanese Healthy Subjects
|
Phase 1 | |
| Enrolling by invitation |
NCT06037564 -
B-free Multistage Trial
|
Phase 4 | |
| Completed |
NCT05123820 -
Pharmacokinetics of Omeprazole and Midazolam When Co-administered With ACT-1014-6470
|
Phase 1 | |
| Recruiting |
NCT04840862 -
Impact of Rifabutin on the Pharmacokinetics of Elexacaftor/Tezacaftor/Ivacaftor
|
Phase 4 | |
| Completed |
NCT01350921 -
Evaluation of the Drug-drug Interaction Between Ticagrelor and Venlafaxine When Taken Together in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT03103568 -
A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT04840641 -
Flucloxacillin as an Inducer of CYP-enzymes
|
Phase 1 | |
| Completed |
NCT05845567 -
The Potential of Givinostat as DDI Victim in Co-administration P-gp Inhibitor (Part 2)
|
Phase 1 | |
| Completed |
NCT05304845 -
Drug-drug Interactions Between DWP14012 and Aspirin in Healthy Subjects
|
Phase 1 | |
| Completed |
NCT05860114 -
Givinostat and Metabolites Pharmacokinetics in Urine and Plasma (Part 3)
|
Phase 1 | |
| Completed |
NCT04776499 -
Possible Effects of Propylthiouracil, Riociguat and Perphenazine on Circulation of Healthy Volunteers
|
Phase 1 | |
| Completed |
NCT03909529 -
Drug-drug Interaction (DDI) Study of Spironolactone (Perpetrator) and Digoxin (Substrate Drug)
|
Phase 1 |