DNA Methylation and 1-C Metabolism Nutrient Intake

DNA Methylation Clinical Trial

Official title:

Dietary Intake of One-carbon Metabolism Nutrients and DNA Methylation in Peripheral Blood

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03227003
• Other study ID #: CEID_methylation_1
• Status: Completed
• Phase: N/A
• First received: July 21, 2017
• Last updated: July 21, 2017
• Start date: January 1, 2014
• Est. completion date: December 31, 2015

Study information

• Verified date: July 2017
• Source: Cancer Council Victoria
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The present study used a sub-sample of the Melbourne Collaborative Cohort Study (MCCS) (Milne RL et al, Int J Epidemiol, 2017), who had valid data on dietary intakes (121-item food frequency questionnaire) and valid measures of DNA methylation using the HumanMethylation Infinium 450K Beadchip assay, or using LINE-1, Alu and Sat2 assays.

The investigators studied the association between nutrients involved in one-carbon metabolism and DNA methylation in peripheral blood.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 5983
• Est. completion date: December 31, 2015
• Est. primary completion date: December 31, 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 27 Years to 80 Years

Eligibility

Inclusion Criteria:

• Selected into one of six case-control studies nested in the Melbourne Collaborative Cohort Study

• Completed a 121-item Food Frequency Questionnaire

• Had a blood DNA sample with a measure of methylation

Exclusion Criteria:

• Missing data in any of the outcome, exposure, or confounders (N=797 excluded)

Related Conditions & MeSH terms

• DNA Methylation

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Cancer Council Victoria

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Blood DNA methylation	Methylation of DNA from peripheral blood, HumanMethylation 450 Beadchip assay	2014-2015
Secondary	Blood DNA methylation	Methylation of DNA from peripheral blood, LINE-1, Alu, Sat2	2014-2015