The Effect of Desfluran On Global Dna Methylation

Status Completed

Clinical Trial Summary

The purpose of this study is to demonstrate the molecular effect of desflurane on DNA by measuring the global DNA methylation level in patients under going lumbar spinal stenosis surgery under general anesthesia.

Clinical Trial Description

Forty patients scheduled for lumbar spinal surgery will include in the study. Peripheral venous blood samples will collect prior to the induction of anesthesia (T1) and after 120 minutes (T2). Anesthesia will maintaine with 40%-60% O2-air mixture and 6% desflurane. DNA will obtain from blood samples with the help of DNA isolation kit and global DNA methylation analysis will perform by ELISA method. ;

Study Design

Related Conditions & MeSH terms

DNA Damage

Clinical Trial Details

NCT number	NCT05111717
Study type	Observational
Source	Mugla Sitki Koçman University
Contact
Status	Completed
Phase
Start date	November 17, 2021
Completion date	December 30, 2021

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