DNA Damage Clinical Trial
Official title:
Double Blind, Randomized, Placebo-controlled Clinical Trial of the Effect of Noni Juice on Lipid Peroxidation-derived DNA Adducts in Current Heavy Smokers
Verified date | September 2019 |
Source | Tahitian Noni International, Inc. |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study was to determine if noni juice reduces lipid hydroperoxide (LOOH) and malondialdehyde (MDA) derived-DNA adducts, markers of oxidative DNA damage, in peripheral blood lymphocytes of cigarette smokers.
Status | Completed |
Enrollment | 317 |
Est. completion date | August 2006 |
Est. primary completion date | November 2005 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - 18 to 65 years in age, smoker of more than 20 cigarettes per day, a smoking history exceeding one year, and willing to complete a one month trial. Exclusion Criteria: - concurrent use, or use in the previous three months, of prescription medication or antioxidant vitamins |
Country | Name | City | State |
---|---|---|---|
United States | University of Illinois College of Medicine at Rockford | Rockford | Illinois |
Lead Sponsor | Collaborator |
---|---|
Tahitian Noni International, Inc. | University of Illinois at Chicago |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | LOOH and MDA-DNA adducts | LOOH and MDA-DNA adducts in lymphocytes immediately prior to intervention and at completion of intervention. | 1 month | |
Secondary | adverse events | Adverse health events | 1 month |
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