| Eligibility |
Inclusion Criteria:
- • Male or female patients: 18-65 years old.
- Newly diagnosed patients
- Primary extranodal lymphoma, histologically-confirmed DLBCL( including but not
limited to follicular lymphoma grade 3B, or transformed DLBCL, EBV(+) DLBCL,
ALK(+) DLBCL, high grade lymphoma). The primary site is limited to the
gastrointestinal tract, nasal cavity and breast, and central nervous system( CNS)
involvement must be excluded. Gastrointestinal tract involvement of DLBCL can be
included in the group after evaluation without bleeding or perforation risk.
- ECOG physical condition score: 0-2 points for patients.
- The patients must be with at least one evaluable or measurable lesion meeting
Lugano 2014 criteria, the evaluable lesion was: 18F fluorodeoxyglucose / positron
emission tomography (18FDG-PET) examination showed that the uptake of extranodal
areas was increased (higher than that of liver) and pet and / or computed. The
features of tomography (CT) were in accordance with lymphoma. The measurable
lesions were nodal lesions with a length of > 15 mm or extranodal lesions with a
length of > 10 mm, accompanied by an increase in 18-FDG uptake. It is necessary
to exclude the case where there is no measurable lesion and the diffuse 18-FDG
uptake increase in the liver.
- Hematology values must be within the following limits at baseline:
1. Absolute neutrophil count (ANC) =1,500 cells/µL. In case bone marrow
involvement, ANC=1,000 cells/µL.
2. Platelets=75,000 cells/µL. In case bone marrow involvement, platelets=50,000
cells/µL
3. Hemoglobin=90 g/L
- Biochemical values must be within the following limits at baseline:
1. Alanine aminotransferase(ALT)=3×upper limit of normal (ULN).
2. Aspartate aminotransferase (AST) =3×ULN
3. Total bilirubin=1.5×ULN, unless bilirubin rise is due to Gilbert's syndrome
or of non-hepatic origin.
4. Serum creatinine =2×ULN or estimated Glomerular Filtration Rate
=40/mL/min/1.73m2
- LVEF within institutional normal limits, as determined by echocardiography or
multiple uptake gated acquisition (MUGA) scan.
- Each subject (or their legally acceptable representative) must sigh an informed
consent form (ICF) indicating that he or she understands the purpose of any
procedures for the study and are willing to participate in the study.
- Women of childbearing potential ( WOCBP) must have a negative serum (beta-human
chorionic gonadotropin[ß-hCG] ) or urine pregnancy test within 7 days before the
first medication
- Women of childbearing potential or men and their WOCBP partners should agree to
take effective contraceptive measures from signing the ICF to 6 months after the
last dose of study medication.
Exclusion Criteria:
- • Primary DLBCL arise in lymph nodes or other lymphatic tissues.
- Primary central nervous system lymphoma or secondary central nervous system
involvement, known primary mediastinal lymphoma.
- A history of severe allergies or allergic reactions to humanized or murine monoclonal
antibodies.
- In the past five years, patients with other malignant tumors have undergone radical
treatment, except for basal cell carcinoma of skin, squamous cell carcinoma of skin,
carcinoma in situ of breast and carcinoma in situ of cervix. History of human
immunodeficiency virus (HIV) infection and/or patients with acquired immunodeficiency
syndrome are known
- Patients with active hepatitis B or active hepatitis C. Patients who are positive for
hepatitis B Surface Antigen (HBsAg) or hepatitis C Virus (HCV) antibodies at screening
stage must pass further detection of hepatitis B Virus (HBV) DNA titer (no more than
2500 copies/mL or 1000 IU/mL) and HCV RNA (no more than the lower limit of the
detection method) in the row. In addition to active hepatitis B or hepatitis C
infections requiring treatment, group trials can be conducted. Hepatitis B carriers,
stable hepatitis B (DNA titer should not be higher than 2500 copies/mL or 1000 IU/mL)
after drug treatment, and cured hepatitis C patients can be enrolled in the group.
- Patients with any active infections requiring systemic anti-infective treatment within
14 days of treatment.
- Received systemic antineoplastic therapy within 28 days before treatment, including
chemotherapy, immunotherapy, biotherapy (cancer vaccine, cytokines, or growth factors
that control cancer), etc..
- Received major surgery within 28 days before treatment or radiotherapy within 90 days
before treatment.
- Received live vaccination (except influenza attenuated vaccine) within 28 days before
treatment.
- Patients requiring long-term systemic glucocorticoid therapy or other
immunosuppressive therapy (>prednisone 10mg/qd or equivalent dose of other
glucocorticoid therapy). Allowing subjects to use local, ocular, intra-articular,
intranasal and inhaled glucocorticoid therapy.
- Patients suffering from uncontrollable comorbid diseases, including but not limited to
symptomatic congestive heart failure, uncontrollable hypertension, unstable angina,
active peptic ulcer or bleeding disorders.
- Pregnant or lactating women.
- Patients with a history of interstitial lung disease or non-infectious pneumonia.
Subjects who have previously had drug-induced or radioactive non-infectious pneumonia
but asymptomatic are allowed to enroll.
- Any life-threatening disease, physical condition or organ dysfunction according to the
researchers' judgment may endanger the safety of the subject or put the clinical
research at excessive risk.
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