Diverticulitis Clinical Trial
Official title:
Diverticular Disease Register (REMAD)
To determine the clinical characteristics and risk factors for the onset of diverticular disease and its complications in the Italian population.
Diverticulosis and diverticular disease present a high prevalence rate in the world
population, especially in the Western world. Diverticulosis of the colon is an extremely
common condition in industrialized countries and its prevalence rate increases with age, and
exceeds 60% in patients aged over eighty. Although the course of diverticulosis is normally
free of symptoms and complications, about 15% of patients develop symptoms often
undistinguishable from those of the irritable bowel syndrome, such as abdominal pain, bowel
disorders and bloating. About 5% of patients with diverticular disease develop an episode of
uncomplicated acute diverticulitis with abdominal symptoms accompanied in some cases by
systemic symptoms, such as fever or malaise and laboratory evidence of activation of the
inflammatory process. In a minority of these cases, the patient suffers major complications
such as the development of abscesses, fistulae, haemorrhage or stenosis (1).
The pathogenesis of diverticulosis and diverticular disease remains unclear. Genetic
predisposition, risk factors (2), relationships with the irritable bowel syndrome (3-5), a
low-fibre diet, involvement of intestinal microbiota and the mucosal immune activation (6-7)
remain elements whose significance is yet to be confirmed. The management, medical and
surgical approach and the prevention of relapses of diverticular disease remain above all
empirical and supported by few controlled clinical studies (8-9). This scenario of
uncertainty may result in waste and diagnostic/therapeutic pathways not always suitable for a
disease with such a high prevalence rate. On the basis of these considerations, there is a
need to collect systematic information useful for determining aetiopathogenetic aspects and
outcomes with greater accuracy.
OBJECTIVES OF THE STUDY
The purpose of the study is to structure a national register on an IT platform useful for
determining:
1. The clinical aspects of diverticulosis/ diverticular disease
2. The risk factors of diverticulosis/ diverticular disease
3. The risk of complications of diverticular disease and the factors of risk and protection
against complications.
4. The management of medical and surgical treatments
;
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