Diffuse Large B Cell Lymphoma Clinical Trial
Official title:
Phase III,Randomized Controlled Trial of R-GemOx Versus R-miniCHOP Regimen in First-line Treatment of Elderly Diffuse Large B Cell Lymphoma
The purpose of this study is to investigate efficacy and safety of R-GemOx Versus R-miniCHOP as first-line treatment of elderly patients with Diffuse large B cell lymphoma
Gemcitabine and Oxaliplatin(GemOx) shows effective activity in patients with relapsed diffuse
large-cell lymphoma and other solid tumors. Our Previous study showed that two-weekly regimen
of rituximab combined with GemOx regimen acheived comparable response rate to R-miniCHOP.The
investigators therefore design this open-label,phase III and random trial to compared the
safety and efficacy of R-Gemox versus R-miniCHOP as first-line treatment of elderly patients
with diffuse large B cell lymphoma.
Primary Outcome Measures:
• 2-year overall survival rate
Secondary Outcome Measures:
- 2-year progression free survival rate
- overall response rate
- safety and toxicity Enrollment:258 Study Start Date: June 2016 Primary Completion Date:
June 2019
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