Diffuse Large B-cell Lymphoma Clinical Trial
Official title:
The Use of 18 F-FDG Positron Emission Tomography (PET) in the Early Response Evaluation of Diffuse Large B-cell Lymphoma.
Non-Hodgkin lymphoma (NHL) is one of the more frequent cancers in the western world with
approx. 800 new cases annually in Denmark. Diffuse large B-cell lymphoma (DLBCL) in Denmark
accounts for almost 40% of newly diagnosed NHL cases. Treatment with the combination of
chemotherapy and monoclonal antibodies has significantly improved prognosis over the past
decade, but a large proportion of patients with DLBCL will continue to relapse with our
current treatment options. Therefore, there is a need for reliable methods for detection of
treatment response as early as possible in the treatment course in order to identify
patients who respond poorly to standard treatment and potentially would benefit from a
change in treatment strategy. This has still not been established, but a valid early marker
is required in order to allow randomized trials of treatment stratified by early response.
One of the most promising applications of PET is the metabolic assessment of the early
response of cancer treatment.
This study is a national prospective multicenter study emanating from the Danish Lymphoma
Group (DLG). Patients are scanned after each of the early 4 cycles of chemo therapy. The aim
is to establish the correct timing of response evaluation. Additionally, the investigators
wish to investigate the optimal qualitative and quantitative method of response assessment
in order to predict post-therapeutic remission and long-term prognosis.This study will
contribute to interim-PET being implemented in the most optimal way in daily clinical
practice.
n/a
Observational Model: Cohort, Time Perspective: Prospective
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