Diffuse Large B-cell Lymphoma Clinical Trial
Official title:
Retrospective Analysis of Diffuse Large B-cell Lymphoma: Identification of Factors Associated With Treatment Resistance Via Gene Expression Profile
| Verified date | January 2013 |
| Source | Samsung Medical Center |
| Contact | n/a |
| Is FDA regulated | No |
| Health authority | Korea: Institutional Review Board |
| Study type | Observational |
The investigators perform a retrospective microarray gene expression profiling study of FFPE from a cohort of DLBCL patients with whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay. The investigators also study the pattern of microRNA from patients with diffuse large B-cell lymphoma. The results of gene expression profiles and microRNA is correlated with clinical outcomes of diffuse large B-cell lymphoma.
| Status | Completed |
| Enrollment | 350 |
| Est. completion date | December 2012 |
| Est. primary completion date | December 2012 |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 15 Years to 90 Years |
| Eligibility |
Inclusion Criteria: - Patients diagnosed with diffuse large B-cell lymphoma - Patients with tissue blocks available for study - Patients with adequate medical records Exclusion Criteria: - Patients diagnosed with other subtypes of lymphoma |
Observational Model: Cohort, Time Perspective: Retrospective
| Country | Name | City | State |
|---|---|---|---|
| Korea, Republic of | Samsung Cancer Research Institute | Seoul |
| Lead Sponsor | Collaborator |
|---|---|
| Samsung Medical Center |
Korea, Republic of,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | Number of patients who relapse or progress after 1st line chemotherapy | two years | No | |
| Secondary | Number and type of genes and microRNA which are significantly related with relapse or progression (P < 0.05) | two years | No |
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