Diffuse Large B-cell Lymphoma Clinical Trial
Official title:
Yt90Zevalin Plus CHOP, Z-CHOP
The purpose of this study is to determine whether the treatment of Yt90 Zevalin in combination with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone)are effective as first line treatment in patients with bulky stage II or stage III or IV diffuse large B-cell lymphoma
Radioimmunotherapy represents a significant advance over unlabeled immunotherapy for the
treatment of patients with B-cell non-Hodgkin's lymphoma. The radiobiological effects
associated with Yt90-labelled ibritumomab tiuxetan (Zevalin) include the induction of
apoptosis and cell-cycle redistribution.
The response rate tend to be higher in patients who have been treated with fewer prior
therapies and Yt90-labelled ibritumomab tiuxetan may be suitable for use early in the course
of therapy.
Yt90-labelled ibritumomab tiuxetan has less non hematologic toxicity than chemotherapy, with
only minimal alopecia, mucositis, nausea, or vomiting, and a lower incidence of infections.
Yt90-labelled ibritumomab tiuxetan regimen is routinely and safely given in an outpatient
setting and is completed in 7-9 days and is thus more convenient to be used.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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