Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males

Dietary Supplementation Clinical Trial

Official title:

Effects of Combined Grape Seed Extract and L-citrulline Supplementation on Hemodynamic Responses in Young Males

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05116150
• Other study ID #: 112-1819 EXP
• Status: Completed
• Phase: N/A
• Start date: June 1, 2019
• Est. completion date: December 1, 2019

Study information

• Verified date: November 2021
• Source: California Baptist University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study was to examine the additive benefits with combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study.

Description:

The investigators aimed the additive effects of combined grape seed extract (GSE) and L-citrulline supplementation on hemodynamic responses to dynamic exercise, 11 young, healthy males were recruited for this study. Effects of 7 days of combined GSE with L-citrulline supplementation on systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), cardiac output (CO), total vascular conductance (TVC), and oxygen consumption (O2) were examined at rest and during cycling exercise.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 11
• Est. completion date: December 1, 2019
• Est. primary completion date: December 1, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• healthy males

Exclusion Criteria:

• cardiovascular and/or pulmonary disease, musculoskeletal disorders, or medications that prevent the safe completion of the exercise protocol

Related Conditions & MeSH terms

• Dietary Supplementation

Intervention

Dietary Supplement:
• Grape seed extract
Effects of 7 days of combined GSE with L-citrulline supplementation on hemodynamic responses at rest and during cycling exercise.
• Placebo
Effects of 7 days of placebo supplementation on hemodynamic responses at rest and during cycling exercise.

Locations

Country	Name	City	State
United States	California Baptist University	Riverside	California

Sponsors (1)

Lead Sponsor	Collaborator
California Baptist University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Systolic blood pressure (mmHg)	by sphygmomanometer	7 days
Primary	Diastolic blood pressure (mmHg)	by sphygmomanometer	7 days
Primary	Mean arterial pressure (mmHg)	calculated (MAP = (SBP-DBP)/3 + DBP	7 days
Primary	Heart rate (bpm)	measured using Physio Flow (non-invasive device)	7 days
Primary	Stroke volume (ml)	measured using Physio Flow (non-invasive device)	7 days
Primary	Cardiac output (l/min)	calculated: HR (bpm) x SV (ml)	7 days
Primary	Total vascular conductance (ml/min/mmHg)	calculated: CO (ml/min) / MAP (mmHg)	7 days