Acute Effects of Dietary Medium-chain Fatty Acids on Lipid Profile

Diet, Healthy Clinical Trial

— Lipidomix  

Official title:

Acute Effects of Dietary Medium-chain Fatty Acids on Llipid Profile

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06368271
• Other study ID #: Lipidomix
• Status: Completed
• Phase: N/A
• Start date: October 1, 2021
• Est. completion date: February 28, 2024

Study information

• Verified date: April 2024
• Source: University of Copenhagen
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In the present study the plasma lipid profile was elucidated in healthy, lean males by the use of lipidomic analysis in the hours after an acute intake of medium-chain fatty acids (MCT) and long chain fatty acids (LCT),, respectively. In addition oxygen uptake was measured to study energy turnover.

Description:

Four participants ingested MCT or LCT oil on two test days with one-week period between the experimental days. The day prior to the experimental days, the participants consumed a eucaloric control diet, and abstained from alcohol and vigorous physical activity to ensure similar conditions on experimental days.

On the test days, participants arrived by passive transport in the overnight fasted state (12 h) at 8 a.m., and a catheter was inserted into an antecubital vein. Following 30 min in supine rest, an overnight-fasted, basal venous blood sample was obtained. Subsequently, participants ingested the same test drink as in study 1 (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carbohydrate cocoa milk) within five min. 100 ml water was provided together with the test drink. Venous blood samples were drawn every 30 min for the first two hours and every 60 minutes for the last two hours following intake. Participants rested in a bed throughout the test day. this This process was repeated on the second test day.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 4
• Est. completion date: February 28, 2024
• Est. primary completion date: February 28, 2024
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 20 Years to 30 Years

Eligibility

Inclusion Criteria:

healthy males BMI:20-27 recreationally physical active non-smoker no medicine

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Exclusion Criteria:

• high habitual intake of MCT-rich foods as coconut, coconut oil and dairy products

Related Conditions & MeSH terms

• Diet, Healthy

Intervention

Dietary Supplement:
• Lipidomics
Health beneficial effects of medium-chain fatty acids

Locations

Country	Name	City	State
Denmark	Department of Nutrition, Exercise and Sports	Copenhagen
Denmark	University of Copenhagen	Copenhagen

Sponsors (1)

Lead Sponsor	Collaborator
University of Copenhagen

Country where clinical trial is conducted

Denmark, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Meal test including medium-chain fatty acids	In this study the effect of an acute intake of MCT oil compared with the intake of LCT (containing 35g of MCT or LCT oil diluted in 100g of low-fat, low-carb cocoa milk ) on the plasma lipid profile is studied in healthy men. Blood is obtained postprandially ( frequently during 4 hours) and analyzed for the plasma lipid profile	0-4 hours
Secondary	Resting metabolic rate	The secondary outcome of this study is to investigate the effect of an acute intake of MCT or LCT oil (35g of MCT or LCT) on resting metabolic rate in healthy lean men	0-4 hours