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Clinical Trial Summary

The study plans to start in July 2021, and it is expected that 20 healthy people (aged 18-70 years old, BMI 18.5-40kg/m2) will carry out a 5-week intervention and follow-up. Participants will be enrolled in the group through the screening and plan to take regular diet, OGTT, high-fat diet, low-calorie diet and ketogenic diet within 5 weeks. The proteomics and metabolomics indicators of tear, plasma, and urine specimens will be measured at 5 time points at baseline, 30 minutes, 1 hour, 2 hours, and 3 hours for each diet. The correlation of proteomics and metabolomics indicators with classic laboratory parameters (BMI, HDL, LDL, cholesterol, triglyceride levels, and insulin resistance (HOMA-IR)) will be analyzed.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04984642
Study type Interventional
Source Second Affiliated Hospital, School of Medicine, Zhejiang University
Contact Pengfei Shan, MD
Phone +86 13958039665
Email pengfeishan@zju.edu.cn
Status Recruiting
Phase N/A
Start date July 1, 2021
Completion date October 1, 2021

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