Effect of Exercise on Heart Function in Healthy Elderly People

Diastolic Dysfunction Clinical Trial

Official title:

Aerobic Interval Training Reduces and Compensates Age Related Decline in Cardiac Function

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00804518
• Other study ID #: 4.2008.2177
• Status: Completed
• Phase: N/A
• First received: December 8, 2008
• Last updated: July 15, 2016
• Start date: November 2008
• Est. completion date: August 2009

Study information

• Verified date: July 2016
• Source: Norwegian University of Science and Technology
• Contact: n/a
• Is FDA regulated: No
• Health authority: Norway: Norwegian Social Science Data Services
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to determine the effect of aerobic interval training on left- and right ventricular diastolic- and systolic function on healthy, sedate people over 70 years. The old sedate cohort will be compared to young, sedate subjects also performing aerobic interval training and old master athletes without intervention.

Description:

Aging is associated with a reduced diastolic and systolic function of the heart. Earlier studies have shown that physical exercise can improve both systolic and diastolic function. However the impact on age-related cardiac function is to some extent conflicting. The use of different training intensities will impact on the cardiac result. We have in earlier studies shown aerobic interval training at 90 % of maximal heart rate (4x4 minutes) to have more impact on cardiac function, endothelial function and maximal oxygen uptake compared to moderate intensity.

To our knowledge the effect of aerobic interval training on cardiac function has not been studied in an old, sedate group before.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 45
• Est. completion date: August 2009
• Est. primary completion date: March 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 70 Years and older

Eligibility

Inclusion Criteria:

• over 70 years, healthy

• not exercising more than twice per week

Exclusion Criteria:

• chronic illness

• chronic use of any medication

• regular smoking

• metabolic or cardiovascular diseases

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Diastolic Dysfunction

Intervention

Other:
• Aerobic interval training
High intensity aerobic interval training consists of 10 minutes warm up at ~60% of maximal heart rate, 4x4 minutes intervals at 90-95 % of maximal heart rate corresponding to 85-90% of VO2max) walking/running uphill on a treadmill, with three minutes active pause between the exercise bouts at 60-70% maximal heart rate. The session is terminated with 3 minutes cool down. Total exercise time is 38 minutes.The training is supervised by an exercise physiologist and the subjects train 3 times per week for 12 weeks.

Locations

Country	Name	City	State
Norway	Ntnu/Dmf/Isb	Trondheim	Sør-Trøndelag

Sponsors (1)

Lead Sponsor	Collaborator
Norwegian University of Science and Technology

Country where clinical trial is conducted

Norway, 

References & Publications (1)

Molmen HE, Wisloff U, Aamot IL, Stoylen A, Ingul CB. Aerobic interval training compensates age related decline in cardiac function. Scand Cardiovasc J. 2012 Jun;46(3):163-71. doi: 10.3109/14017431.2012.660192. Epub 2012 Feb 20. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Improvement of left and right ventricular early diastolic tissue velocity at rest and sub maximal exercise ,e'.		12 weeks	No
Secondary	Improvement of left and right ventricular systolic tissue velocity function at rest and sub maximal exercise, S'.		12weeks	No