Diarrhea Clinical Trial
Official title:
Chemotherapy-driven Dysbiosis in the Intestinal Microbiome
Chemotherapy is commonly used as myeloablative conditioning treatment to prepare patients
for haematopoietic stem cell transplantation (HSCT). Chemotherapy leads to several side
effects, with gastrointestinal (GI) mucositis being one of the most frequent. Current models
of GI mucositis pathophysiology are generally silent on the role of the intestinal
microbiome.
The aim of the study is to identify functional mechanisms by which the intestinal microbiome
may play a key role in the pathophysiology of GI mucositis, the investigators applied high
throughput DNA-sequencing analysis to identify microbes and microbial functions that are
modulated following chemotherapy.
n/a
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