Mass Oral Cholera Vaccination in Zanzibar

Diarrhea Clinical Trial

Official title:

Mass Oral Cholera Vaccination in High-risk Populations in Zanzibar: Assessment of Effectiveness and Herd Protection

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00709410
• Other study ID #: DK - 02
• Status: Completed
• Phase: N/A
• First received: July 1, 2008
• Last updated: March 29, 2012
• Start date: January 2009
• Est. completion date: December 2011

Study information

• Verified date: March 2012
• Source: International Vaccine Institute
• Contact: n/a
• Is FDA regulated: No
• Health authority: Zanzibar: Ministry of Health and Social Welfare
• Study type: Interventional

Clinical Trial Summary

The purpose of this study is to conduct cholera vaccinations in high-risk populations in Zanzibar in order to estimate herd protection conferred by the vaccine,estimate effectiveness of the vaccine, and describe the interaction of vaccination and improved water supply on the burden of cholera and diarrhoeal diseases.

Description:

The seventh cholera pandemic began in Indonesia in 1961 and spread quickly to other Asian countries. In 1970, the etiologic agent, Vibrio cholerae O1 El Tor, invaded sub-Saharan Africa, whose residents had not experienced cholera for more than 100 years. Outbreaks rapidly occurred and the disease has become endemic in several parts of the continent. In 2006, Africa reported 234,349 cholera cases to the WHO, accounting for 99% of the officially-notified global cholera (1). Between 1995 and 2005, 66% of cholera outbreak reports to ProMed came from sub-Saharan Africa (2). There is growing evidence of the large and increasing burden of cholera in Africa.

One African country that is severely and repeatedly affected by cholera is Zanzibar. After the first case of cholera was confirmed in the country in January 1978, regular outbreaks have been reported (3). These outbreaks cause human suffering, are socially disruptive, and divert resources from other essential services. Cholera control in Zanzibar has focused mainly on case management, water chlorination campaigns, and dissemination of hygiene messages. The Ministry of Health and Social Welfare (MOHSW) is eager to identify new and effective tools, such as oral cholera vaccination, that could be implemented in Zanzibar.

In 2002, the World Health Organization (WHO) recommended the potential use of oral cholera vaccines in endemic and epidemic situations, but it was deemed necessary to gain more experience through demonstration projects (4). Since then, mass oral cholera vaccinations have been conducted in Beira, Mozambique (5), in Darfour, Sudan, and in Aceh, Indonesia which demonstrated the feasibility and effectiveness of vaccination under actual public health conditions. The only oral cholera vaccine available in the market consists of killed whole-cell V. cholerae O1 with purified recombinant B-subunit of cholera toxin (WC/rBS) administered with a buffer solution as two doses, at least a week apart. The vaccine is internationally-licensed (including in Zanzibar) for use in individuals 2 years of age and older. This vaccine, and its predecessor (BS-WC) that contained chemically extracted rather than recombinant cholera toxin B subunit, have been shown to be safe and protective in several trials conducted in cholera-endemic settings in Asia and South America (6-9) and in a sub-Saharan African setting with a high prevalence of HIV (5).

An incompletely answered question regarding this vaccine is its potential to confer herd protection (10). The level of herd immunity would determine the minimum vaccine coverage required to produce widespread protection against cholera in a community. A recent study comparing cholera rates in sites in Asia and Africa has shown that the burden of cholera is greatest in young children (11); herd immunity would provide protection for children too young to receive the vaccine, as well as other unvaccinated members of the community. Although recent re-analysis of data from the large placebo-controlled field trials of the oral cholera vaccine in Bangladesh in the 1980s showed substantial herd protection from vaccination (12,13), there may be limitations to the applicability of these findings to other cholera endemic settings with different living conditions (14). Mathematical modelling of the same Bangladesh data found that cholera transmission could be controlled in endemic areas with 50% vaccine coverage. At this level of coverage, the model predicted that there would be an 89% reduction in cholera cases among the unvaccinated, and a 93% reduction overall in the entire population. A more modest coverage of 30% would result in a 76% reduction in cholera incidence for the population area covered (15). If confirmed in actual field studies, these mathematical predictions have major vaccine cost-effectiveness implications.

We propose to carry out mass oral cholera vaccinations in populations at high risk for cholera in Zanzibar followed by an assessment of direct and indirect protection. The WHO was awarded a grant by the Bill and Melinda Gates Foundation entitled: "Pre-emptive use of a cholera vaccine in vulnerable populations at risk", under which this proposal will be funded. The 6 million US$ grant aims to address issues regarding the potential utilization and mechanism of pre-emptive delivery of the vaccine to prevent outbreaks in endemic regions. An important component is the potential creation of a "revolving" stock of vaccine and the financial sustainability of maintaining such a stockpile.

The lessons learned from this project will be crucial for informed decisions about the potential wider use of cholera vaccination in Zanzibar and other cholera-endemic sub-Saharan African countries. The lessons learned from the effectiveness study will form part of the evidence for the possible establishment of a sustainable vaccine stockpile. The project would provide essential information on the vaccine coverage required to control cholera in endemic areas and additional data on vaccine effectiveness in a different setting in Africa.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 51151
• Est. completion date: December 2011
• Est. primary completion date: February 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 2 Years and older

Eligibility

Inclusion Criteria:

• Healthy residents of selected vaccination sites

• Aged 2 years and older

• non-pregnant

Exclusion Criteria:

• Age less than 2 years

• Pregnant

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention

Related Conditions & MeSH terms

• Cholera
• Diarrhea

Intervention

Biological:
• rBS-WC vaccine
1 mg of recombinant cholera toxin B subunit and approximately 1 x 10^11 of inactivated whole cells of Vibrio cholerae O1 Inaba and Ogawa, classic and El Tor strains (6). The rBS-WC vaccine is supplied as 3 ml single-dose vials each with a sachet of sodium bicarbonate buffer. Buffer solution will be prepared by dissolving the sachets in drinking water (150 ml water for each sachet of sodium bicarbonate). The full dose of vaccine will be mixed with 40, 75, or 150 ml of buffer solution for persons 2 to 4 years, 5 to 11 years, and over 11 years old, respectively. The vaccine is recommended to be given in two doses with an interval of at least seven days and protection is conferred 7 to 10 days after the second dose.

Locations

Country	Name	City	State
Tanzania	Ministry of Health and Social Welfare, Zanzibar	Zanzibar

Sponsors (5)

Lead Sponsor	Collaborator
International Vaccine Institute	Bill and Melinda Gates Foundation, Ministry of Health and Social Welfare, Zanzibar, National Institute of Cholera and Enteric Diseases, India, World Health Organization

Country where clinical trial is conducted

Tanzania, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Receipt of 2 complete or nearly complete swallowed doses of oral cholera vaccine		after completion of the vaccination campaign	No
Secondary	Acute, non-bloody diarrhoea severe enough to seek care at the Primary Health Care Units		starting 10 days following vaccination campaign	No