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Diacerein clinical trials

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NCT ID: NCT04351100 Completed - Osteoarthritis Clinical Trials

Efficacy of Diacerein on Ocular Surface Disease in Degenerative Arthritis Patients

Start date: October 1, 2019
Phase:
Study type: Observational

Dry eyes is multi-factorial disease which inflammation play etiological role. Diacerein is drug which has anti-inflammatory effect by antagonist Interleukin-1, decrease Interleukin-1 receptor, increase Interleukin-1 Receptor antagonist. This observational study enrolled participants who going to take diacerein for osteoarthritis, measure corneal staining score, Ocular surface disease index score, Tear Osmolarity, Tear break up time, Schirmer 1 test, Interleukin-1 Receptor antagonist, Interleukin-1 alpha, Interleukin-1 beta level in tear at the time of enrollment and after 2 months.

NCT ID: NCT01906801 Completed - Osteoarthritis Clinical Trials

Clinical Efficacy of Glucosamine Plus Diacerein Versus Mono-therapy of Glucosamine

Start date: July 2013
Phase: Phase 4
Study type: Interventional

The purpose of this study is to compare pain scores, WOMAC total and subscores, actual and change of joint space width and the rate of gastrointestinal side effects at 4, 8, 12, and 24 weeks between dual-therapy of diacerein and glucosamine versus a mono-therapy of glucosamine in OA patients