Diabetic Ulcers on Both Feet Clinical Trial
Official title:
Treatment and Evaluation of Platelet-rich-plasma on Diabetes Wound Healing
The purpose of this study is to focus on the effect of platelet-rich-plasma on diabtic ulcer foot, as adjuvant treatment along with the standard care of chronic diabetic, and evaluate the efficiency and the clinical application of PRP on serious wound healing.
Diabetes is a condition in which the body dose not effectively use sugar so that there is
too much sugar in the blood. It is estimated that 15% of the diabetics suffer from diabetic
food ulcers at some point. The healing process can be slow and easily to be infected with
some pathogens so the patients are at risk in amputation. The wound healing process is a
complex mechanism involves the interaction of molecular signals and different cell types.
Platelets play important roles in wound healing. When injury occurs platelets are activated
with thrombin and clot is formed. In addition to the function of hemostasis, activated
platelets release many growth factors that trigger angiogenesis, extracellular matrix
production and cytokine release, which is need for wound healing.
Platelet-rich plasma (PRP) is a portion of plasma fraction of autologous blood having a high
concentration of thrombocytes. Thrombin induces the activation of PRP and results in the
release of multiple growth factors, including platelet-derived growth factor (PDGF),
vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like
growth factor (IGF), and transforming growth factor beta (TGF-β). PRP is known for the
capacity to stimulate cell proliferation and differentiation. PRP can also interact with
macrophage to improve tissue healing and regeneration, and exhibit potent activities against
several kinds of pathogens.
Our study will focus on the advantage of PRP for aiding wound healing for diabetes. PRP from
autologous blood can be mixed with thrombin in appropriate ratio and inject into the sites
around the wound, as adjuvant treatment along with the standard care of chronic diabetic.
The wound will be checked 1 to 2 times each week for the evaluation of PRP on clinical
application.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT04078854 -
The Impact of Sexual Health and Amputation Focused Education on Regulation of Glucose and Amputation Prevention
|
N/A |