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Progression of Diabetic Retinopathy. Identification of Signs and Surrogate Outcomes — PROGRESS  

Diabetic Retinopathy Clinical Trial

Official title:
PROGRESS - Progression of Diabetic Retinopathy. Identification of Signs and Surrogate Outcomes

Clinical Trial Summary

Progression of Diabetic Retinopathy. Identification of Signs and Surrogate outcomes (PROGRESS)

Clinical Trial Description

The global aim of this study is to improve the current knowledge of diabetic retinopathy (DR) progression. We aim to characterize both functionally and morphologically initial DR stages and to identify patients at risk of progression to centre involving macular oedema (CME) and/or proliferative diabetic retinopathy (PDR). We want to identify imaging patterns and characteristics that might be used as prognostic biomarkers for DR progression.

For this, ischemia and blood-retinal barrier alteration will be assessed using non-invasive retinal imaging methodologies. SD-OCT with layer-by-layer segmentation will be performed. Furthermore, a state-of-the-art methodology with OCT-Angiography will be used for identification of areas of capillary drop-out and leakage areas will be identified on SD-OCT without the need of a dye injection. In a subgroup of patients we will study neurodegeneration patterns using multifocal ERG examination. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03010397
Study type Observational [Patient Registry]
Source Association for Innovation and Biomedical Research on Light and Image
Contact
Status Completed
Phase
Start date December 2016
Completion date March 6, 2019
View Details
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