Diabetic Retinopathy Clinical Trial
Official title:
Comparison of Diabetes Retinopathy Among Type 2 Diabetic Patients Treated With Different Regimens: a Multicentre Randomized Parallel-group Clinical Trial
Diabetic retinopathy (DR) is an important cause of blindness.
Diabetic retinopathy (DR) is an important cause of blindness, and its development of an
irreversible process. DR is not only the overall progress and the level of blood sugar, and
blood glucose fluctuations more closely, is the key to a smooth hypoglycemic delay DR
progression.Diabetes control and complication trail(DCCT) study shows that even though
glycemic control was no significant difference in blood glucose fluctuations ,DR also have a
significant difference. In this study, three different glucose-lowering program for: (A) a
single oral anti-diabetic drugs, (B) basal insulin and oral anti-diabetic drugs, (C)
premixed insulin and oral anti-diabetic drugs for comparison. Focus on the stability and the
impact of these three programs hypoglycemic long-term prognosis of the DR, and thus affect
the molecular mechanisms of DR-based exploration of glucose fluctuations, to optimize blood
glucose solutions, lower blood sugar steady, slow progression of DR ultimate clinical
purposes.
The multi-center study is to cooperate, enrolled 600 cases of type 2 diabetes, observe the
effects of different solutions on blood sugar glucose fluctuations and retinopathy, a total
of 5 years of follow-up. This will be the first at home and abroad to compare the incidence
of hypoglycemic effect programs on DR large multi-center, randomized, controlled clinical
studies, clinical practice will optimize the treatment of type 2 diabetes theoretical and
evidence-based medicine.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
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