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NCT02026843 Clinical Trial

Analysis of Angiogenic Factor Levels in Eyes With Diabetic Retinopathy

Diabetic Retinopathy Clinical Trial

Official title:
Analysis of Angiogenic Protein and Anti-angiogenic Levels in Eyes With Diabetic Retinopathy.

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT02026843
Other study ID # KNUH2013-1
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date April 2012
Est. completion date April 2022

Study information
Verified date February 2021
Source Kyungpook National University Hospital
Contact Dong Ho Park, M.D.
Phone 82-53-420-5813
Email sarasate2222@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study was conducted to investigate the levels of angiogenic factors and anti-angiogenic factors in the aqueous humor of patients with diabetic retinopathy.

Description:

This prospective, case-control study included 50 patients(50eyes) with severe nonproliferative diabetic retinopathy or proliferative diabetic retinopathy and 50 patient with nondiabetic retinopathy or cataract. Aqueous humor was taken before injection of anti-vascular endothelial growth factor agent or pars plana vitrectomy for other retinal disease. Angiogenic and non-angiogenic proteins were analyzed.

Recruitment information / eligibility
Status Recruiting
Enrollment 100
Est. completion date April 2022
Est. primary completion date February 2022
Accepts healthy volunteers No
Gender All
Age group 20 Years to 80 Years
Eligibility Inclusion Criteria: - age over 20 years - diabetic patients requiring opthalmologic treatments for different degrees of decreasing of visual acuity. - diabetic patients requiring intravitreal injection,cataract surgery or vitrectomy - nondiabetic patients asking cataract surgery or vitrectomy for posterior segment nonproliferative disorders. Exclusion Criteria: - under the age of 20 years - patients that received any anti-vascular endothelial growth factor agent for proliferative disease before taking sample of aqueous humor - patients that did not signed the informed consent of the trial - patients with intraocular inflammations or infections that requiring any pharmaceutical agent - patients with recent ocular trauma

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
Korea, Republic of Dong Ho Park Daegu Kyungsangpookdo

Sponsors (1)
Lead Sponsor Collaborator
Kyungpook National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome
Type Measure Description Time frame Safety issue
Primary Aqueous secretory angiogenic and anti-angiogenic protein concentration To establish if certain type of diabetic retinopathy and nondiabetic retinal disease group are associated to different concentrations of angiogenic or anti-angiogenic protein concentration. one month
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