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Pharmacological Intervention in Diabetic Retinopathy — XAVOT  

Diabetic Retinopathy Clinical Trial

Official title:
Pharmacological Intervention Against Diabetic Retinal Flow Disturbances.

Clinical Trial Summary

The purpose of this study is to determine if diabetic retinopathy can be treated with prostaglandin analogues, prostaglandin synthesis inhibitors or carbonic anhydrases inhibitors.

Clinical Trial Description

Disturbances in retinal perfusion is believed to be involved in the pathophysiology of diabetic retinopathy. These disturbances may be due to changes in the basal diameter of retinal arterioles and to disturbances in the autoregulation of the diameter of these vessels when the blood pressure and the retinal metabolism changes. In vitro studies have shown that prostaglandins and carbonic anhydrases inhibitors are involved in the tone regulation of retinal arterioles, but it is unknown whether this finding is relevant in clinical practice. This can be tested in vivo by an retinal vessel analyzer measuring the dynamics of the retinal vessel diameter changes. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00619034
Study type Interventional
Source University of Aarhus
Contact
Status Completed
Phase N/A
Start date September 2007
Completion date December 2010
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