Efficacy of Paleolithic Diet in Control of Blood Level of Glucose in Type 2 DM Patients

Diabetic Patients Clinical Trial

Official title:

Efficacy of Paleolithic Diet in Control of Blood Level of Glucose in Type 2 DM Patients

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05791019
• Other study ID #: Paleolithic diet and T2DM
• Status: Not yet recruiting
• Start date: June 1, 2023
• Est. completion date: August 1, 2024

Study information

• Verified date: March 2023
• Source: Assiut University
• Contact: Nagy Nageh Abdo, Doctor
• Phone: 01069854486
• Email: nagynageh22[@]gmail.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Efficacy of paleolithic diet in control of blood glucose level in type 2 DM patients

Description:

Diabetes mellitus has become one of the most common progressive chronic diseases in the world, with 422 million people affected worldwide. Approximately 95% of people currently diagnosed with diabetes have type 2 diabetes mellitus (T2DM). The disease is characterized by chronic hyperglycemia, which can impair pancreatic beta cell function and increase insulin resistance, deteriorating the metabolic condition and causing microvascular complications in the retina, kidney or peripheral nerves . Thus, glycemic control is essential for diabetes management, in order to avoid complications in organs and systems, which are related with high morbidity and mortality rates. Among T2DM causes are genetic and epigenetic elements interacting within a societal framework. The genetic predisposition for T2DM takes into account the increased risk of an individual to develop T2DM when there are other family members affected. On the other hand, epigenetic elements are those influenced by environmental factors, i. e., they can be reversible, and therefore manipulated, in order to treat the disease. Regardless of the causes, the main targets of the treatment are focused on decreasing insulin resistance and improving beta cell function and decrease the inflammatory process through diet, exercise and antihyperglycemic agents. Based on this, given the high prevalence of the disease and the significant benefits of its management, it is of clinical importance to determine the proper amount and type of carbohydrates in patients' diet, as they both may influence the glycemic index of a meal. Besides, some foods' intake induce a marked rise followed by a more or less rapid fall in blood glucose, while others produce a smaller peak along with a more gradual decline in plasma glucose. Currently, it is recommended for T2DM patients an intake of 26-44% of total daily energy from carbohydrates, preferably from high-quality sources, such as vegetables, whole fruits and legumes , which are rich in fiber. Most fibers, which are unabsorbed carbohydrates, are insoluble and increase stool weight. In contrast, starches are carbohydrates found in vegetables that are mostly broken down to sugars by digestive enzymes. Resistant starch, also found in vegetables and whole fruits, escapes digestion, being fermented in the intestine as well as dietary fiber. Although the quantity and the quality of carbohydrates in the diet influence blood glucose levels , influencing insulin secretion and gastric emptying, the most beneficial type, the ideal amount of dietary carbohydrates and the underlying mechanisms involved remain a matter of debate. Thus, this study was designed to systematically review the effects of the type and amount of dietary carbohydrates in studies involving T2DM , in order to clarify these aspects for improving T2DM management.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 100
• Est. completion date: August 1, 2024
• Est. primary completion date: July 1, 2024
• Gender: All
• Age group: 20 Years to 45 Years

Eligibility

Inclusion Criteria:

• Newly diagnosed type 2 DM, age less than 45 years old

Exclusion Criteria:

• type 1 DM infection bariatric surgery not follow diet regimine before study at least 6 month not on medication for weight reduction

Related Conditions & MeSH terms

• Diabetic Patients

Intervention

Other:
• Paleolithic diet effect on patients
Efficacy of paleolithic diet in control of blood level of glucose in type 2 DM patients

Locations

Country	Name	City	State
Egypt	Nagy Nageh Abdo	Assiut

Sponsors (1)

Lead Sponsor	Collaborator
Assiut University

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Kleiner A, Cum B, Pisciotta L, Cincione IR, Cogorno L, Prigione A, Tramacere A, Vignati A, Carmisciano L, Sukkar SG. Safety and Efficacy of Eucaloric Very Low-Carb Diet (EVLCD) in Type 1 Diabetes: A One-Year Real-Life Retrospective Experience. Nutrients. 2022 Aug 5;14(15):3208. doi: 10.3390/nu14153208. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Efficacy of paleolithic diet in control of blood glucose levels in type 2 DM patients	Controlling of glucose levels in blood by using specific dietary system and notifying the number of participants who achieve good results	Baseline