Diabetic Neuropathies Clinical Trial
Official title:
The Effectiveness of Strength and Balance Training in Patients With Diabetic Peripheral Neuropathy on Quality of Life and Functional Status: a Randomized Controlled Trial With Cost-utility Analysis
People with diabetes can have nerve damage in their extremities (peripheral neuropathy), and this can lead them to being less able to maintain their balance when they are standing, walking or performing complex movement tasks in their day-to-day life. This results in them being more prone to falls, and consequent injuries. The purpose of this study is to determine whether providing strength and balance retraining (in the form of specific physical exercises or activities) can help people with diabetic peripheral neuropathy regain their ability to maintain their balance, increase their confidence in performing balance-based activities and improve their quality of life.
Individuals with diabetic peripheral neuropathy (DPN) comprise 16-24% of patients with
diabetes mellitus in Singapore, and this is set to rise with the increasing prevalence of
diabetes. DPN is also associated with the greatest reduction in health related quality of
life (HRQoL) among all diabetic complications, specifically PCS (Physical health Component
Summary) and its sub-components, physical functioning and physical role. However, there is
currently no intervention that targets individuals with DPN for improvements in HRQoL and
functional status.
The investigators hypothesise that a targeted intervention providing strength and balance
training will improve HRQoL and functional status in patients with DPN, which will be
sufficiently large relative to increases in cost to make the intervention cost-efficient.
The specific aims of the study are to test the effectiveness of a structured strength and
balance training intervention in 1) improving the physical health component summary (PCS)
measure of health related quality of life, 2) functional status, and 3) assessing
cost-utility of the intervention, in individuals with diabetic peripheral neuropathy (DPN).
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