Diabetic Nephropathy Type 2 Clinical Trial
Official title:
Role of T-regulatory Cells in Type Two Diabetic Nephropathy
Diabetes mellitus is one of the most prevalent health problems worldwide. Diabetic
nephropathy has become the leading cause of end-stage kidney disease worldwide and is
associated with an increased cardiovascular risk.
Traditionally, metabolic and hemodynamic factors are the main causes of renal lesions in
patients with type two diabetes mellitus and diabetic nephropathy , both considered
non-immune diseases. Serial researches has demonstrated that diabetic nephropathy is a
metabolic and hemodynamic disorder, with inflammation playing a vital role in the process.
It has been reported that glomerular basement membranes from diabetic rats induced
significantly greater amounts of Tumor necrotic factor-alpha and Interleukin-1 than when
these cells were incubated with basement membranes from non-diabetic rats.
These new findings were the first to suggest that inflammatory cytokines may participate in
the pathogenesis of diabetic nephropathy .Cluster of differentiation 4 cells are believed to
play central roles in modulating immune responses. Tumor necrotic factor-alpha and
Interleukin-6, and induce inflammation in the pathogenesis of autoimmune diseases.
T- regulatory cells exert immunosuppressive effects which are important on the maintenance of
immune homeostasis by producing anti-inflammatory cytokines, such as Interleukin-10 and
transforming growth factor-b.
Aim of this work is to the role of T regulatory cells :( Cluster of differentiation 4,
Cluster of differentiation 25,Cluster of differentiation 127 , forkhead box P3 cells) in the
different stages of diabetic nephropathy before hemodialysis initiation.
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