Diabetic Nephropathies Clinical Trial
Official title:
Effect of SGLT2 Inhibitor on Proteinuria in Diabetic Patients
Diabetes Mellitus is the leading cause of end stage renal disease. As proven by many studies , controlling proteinuria can delay the progression to end stage renal disease.This work will study the effect of sodium glucose co transporter 2 inhibitor , a new antihyperglycemic drug , on proteinuria and to compare its effect with the effect of classic antiproteinuric drugs as angiotensin converting enzyme inhibitor , aspirin and statins.
Diabetic nephropathy involves progressive stages including glomerular hyperfilteration ,
microalbuminuria , overt proteinuria and a decline in glomerular filteration rate leading to
end stage renal disease.
Despite all the available interventions available for diabetic patients including tight
glycemic control , and blood pressure control , using angiotensin converting enzyme
inhibitors, angiotensin II receptor antagonist renal disease remains prevalent and progress
in these patients.
The newer therapy of diabetes is the use of sodium glucose cotransporter 2 inhibitor as it
has the potential of renoprotection in patients with diabetic nephropathy just as ACEI and
ARBS to reduce glomerular hyperfilteration .This action may reduce albuminuria.
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